Methods and systems are disclosed for antenna resource management in a non-harmonized RF spectrum that enable sharing of antenna structures for multiple wireless applications across different frequency bands in a global market environment and the harmonization of wireless devices in a close proximity environment. Antenna resources are allocated and managed using management software in an environment having multiple antenna resources for use with multiple wireless device types. Management software may control switching logic to retarget the antennas for different association with different types of wireless devices. Policies for selecting wireless devices types may be driven based upon one or more of location awareness, spectrum awareness, and marketing preferences. The wireless devices can be laptop computers, other portable devices, desktop computers, information handling systems, or the like.