发明申请
US20080146631A1 OXAZOLYL-ARYLOXYACETIC ACID DERIVATIVES AND THEIR USE AS PPAR AGONISTS
审中-公开
氧化亚油酸衍生物及其作为PPAR激动剂的用途
- 专利标题: OXAZOLYL-ARYLOXYACETIC ACID DERIVATIVES AND THEIR USE AS PPAR AGONISTS
- 专利标题(中): 氧化亚油酸衍生物及其作为PPAR激动剂的用途
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申请号: US11972668申请日: 2008-01-11
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公开(公告)号: US20080146631A1公开(公告)日: 2008-06-19
- 发明人: Dawn Alisa Brooks , Scott Eugene Conner , Samuel James Dominianni , Alexander Glenn Godfrey , Lynn Stacy Gossett , Christopher John Rito , Allie Edward Tripp , Alan M. Warshawsky , Leonard Larry Winneroski , Guoxin Zhu
- 申请人: Dawn Alisa Brooks , Scott Eugene Conner , Samuel James Dominianni , Alexander Glenn Godfrey , Lynn Stacy Gossett , Christopher John Rito , Allie Edward Tripp , Alan M. Warshawsky , Leonard Larry Winneroski , Guoxin Zhu
- 主分类号: A61K31/421
- IPC分类号: A61K31/421 ; A61P3/06 ; A61P3/10 ; C07D263/32
摘要:
Compounds represented by the following structural formula (I), and pharmaceutically acceptable salts, solvates and hydrates thereof, wherein R1 is an unsubstituted or substituted aryl, heteroaryl, cycloalkyl, aryl-alkyl, heteroaryl-alkyl or cycloalkyl-alkyl, R2 is H, alkyl or haloalkyl, the polymethylene chain (II), is saturated or may contain a carbon-carbon double bond, while n is 2, 3, 4, W is O or S, Y is an unsubstituted or substituted phenylene, naphthylene or 1, 2, 3, 4 tetrahydronaphthylene, R3 is H, alkyl or haloalkyl, R4 is H, alkyl, haloalkyl or a substituted or unsubstituted benzyl, are useful for modulating a preoxisome proliferator activated receptor, particularly in the treatment of diabetes mellitus.