发明申请
US20080161540A1 IL-17A/F heterologous polypeptides and therapeutic uses thereof
审中-公开
IL-17A / F异源多肽及其治疗用途
- 专利标题： IL-17A/F heterologous polypeptides and therapeutic uses thereof
- 专利标题（中）： IL-17A / F异源多肽及其治疗用途
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申请号： US11953733申请日： 2007-12-10
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公开(公告)号： US20080161540A1公开(公告)日： 2008-07-03
- 发明人: David P. Arnott , Austin L. Gurney , Philip E. Hass , James M. Lee , Yan Wu
- 申请人： David P. Arnott , Austin L. Gurney , Philip E. Hass , James M. Lee , Yan Wu
- 主分类号： C07K16/00
- IPC分类号： C07K16/00
摘要：
The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin-17F designated herein as interleukin 17A/F (IL-17A/F). Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, specific antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
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