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发明申请
US20080167498A1 Crystalline venlafaxine base and novel polymorphs of venlafaxine hydrochloride, processes for preparing thereof 审中-公开
盐酸文拉法辛的结晶文拉法辛碱和新型多晶型物，其制备方法

Crystalline venlafaxine base and novel polymorphs of venlafaxine hydrochloride, processes for preparing thereof
摘要：
The present invention relates to novel essentially pure venlafaxine and the process of preparation thereof. The present invention also relates to novel solvate forms of venlafaxine hydrochloride and the process of preparation thereof. Furthermore, the present invention provides a novel process for preparing venlafaxine hydrochloride from venlafaxine; the process comprises the steps of: i) preparing a mixture of venlafaxine with acetone; and ii) exposing the mixture in gaseous hydrochloric acid.
摘要（中）：

本发明涉及新型基本纯粹的文拉法辛及其制备方法。 本发明还涉及文拉法辛盐酸盐的新型溶剂合物形式及其制备方法。 此外，本发明提供了从文拉法辛制备盐酸文拉法辛的新方法; 该方法包括以下步骤：i）制备文拉法辛与丙酮的混合物; 和ii）将混合物暴露在气态盐酸中。

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