发明申请
- 专利标题： Methods for Generating Hypermutable Yeast
- 专利标题（中）： 产生超可变酵母的方法
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申请号： US11930400申请日： 2007-10-31
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公开(公告)号： US20080176329A1公开(公告)日： 2008-07-24
- 发明人: Nicholas C. Nicolaides , Philip M. Sass , Luigi Grasso , Bert Vogelstein , Kenneth W. Kinzler
- 申请人： Nicholas C. Nicolaides , Philip M. Sass , Luigi Grasso , Bert Vogelstein , Kenneth W. Kinzler
- 申请人地址： US MD Baltimore US PA Exton
- 专利权人： The Johns Hopkins University,Morphotek, Inc.
- 当前专利权人： The Johns Hopkins University,Morphotek, Inc.
- 当前专利权人地址： US MD Baltimore US PA Exton
- 主分类号： C12N15/74
- IPC分类号： C12N15/74 ; C12N1/00 ; C12N15/00 ; C12N15/01
摘要：
Yeast cells are mutagenized to obtain desirable mutants. Mutagenesis is mediated by a defective mismatch repair system which can be enhanced using conventional exogenously applied mutagens. Yeast cells with the defective mismatch repair system are hypermutable, but after selection of desired mutant yeast strains, they can be rendered genetically stable by restoring the mismatch repair system to proper functionality.
公开/授权文献
- US07759121B2 Methods for generating hypermutable yeast 公开/授权日：2010-07-20
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