发明申请
US20080176820A1 Use of L-alpha-lysophosphatidylcholine to obtain the differentiation of monocytes into mature dendritic cells in vitro
审中-公开
使用L-α-溶血磷脂酰胆碱在体外获得单核细胞分化成成熟树突状细胞
- 专利标题： Use of L-alpha-lysophosphatidylcholine to obtain the differentiation of monocytes into mature dendritic cells in vitro
- 专利标题（中）： 使用L-α-溶血磷脂酰胆碱在体外获得单核细胞分化成成熟树突状细胞
-
申请号： US12076591申请日： 2008-03-20
-
公开(公告)号： US20080176820A1公开(公告)日： 2008-07-24
- 发明人: Vincent Lotteau , Patrice Andre
- 申请人： Vincent Lotteau , Patrice Andre
- 申请人地址： FR Marcy L'Etoile FR Paris
- 专利权人： BIOMERIEUX,INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
- 当前专利权人： BIOMERIEUX,INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
- 当前专利权人地址： FR Marcy L'Etoile FR Paris
- 优先权： FR02/03499 20020311; FR03/01063 20030130
- 主分类号： A61K31/685
- IPC分类号： A61K31/685 ; A61P29/00
摘要：
The disclosure relates to a method for in vivo differentiation of monocytes in mature dendritic cells, wherein a) monocytes are provided in an appropriate culture medium, b) the monocycles are differentiated in dendritic cells in the presence of a differentiation factor, c) L-α-lysophosphatidylcholine is added to the medium and mature dendritic cells are obtained. The disclosure also relates to the use of at least one inhibitor of L-α-lysophosphatidylcholine in the production of a medicament for the prevention of an inflammation and/or in order to combat an inflammatory disease and/or autoimmune disease.