A chassis partition framework is provided for configuring a personal cluster computer that has a head-node mainboard, a first compute-node mainboard, a second compute-node mainboard, a third compute-node mainboard and a fourth compute-node mainboard. The chassis partition framework mainly includes a top chamber, a left chamber and a right chamber. The top chamber is for configuring the head-node mainboard horizontally. The left and right chambers located under the top chamber are for vertically configuring the first and second compute-node mainboards and the third and fourth compute-node mainboards respectively in face-to-face alignment, with the second and third compute-node mainboards standing in back-to-back alignment. Therefore, the mechanical problems of the conventional blade-type personal cluster computer about heat-dissipation, noise-reduction, expansibility and space-arrangement may be improved through the chassis partition framework.