Multimodal memory controllers are disclosed that include: a transmitter having a first input signal line, a second input signal line, a first output signal line, a second output signal line, a first single-ended driver, a second single-ended driver, a differential transmitter, and a mode control signal line, the mode control signal line having asserted upon it a mode control signal, the transmitter configured to operate the output signal lines using the single-ended drivers at a first voltage when the mode control signal is a first value and to operate the output signal lines using the differential transmitter at a second voltage when the mode control signal is a second value, and the transmitter configured to protect the differential transmitter from the first voltage when the mode control signal is the first value.