发明申请
US20080207552A1 Decoy compositions for treating and preventing brain diseases and disorders
审中-公开
用于治疗和预防脑部疾病和疾病的诱饵组合物
- 专利标题: Decoy compositions for treating and preventing brain diseases and disorders
- 专利标题(中): 用于治疗和预防脑部疾病和疾病的诱饵组合物
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申请号: US11982970申请日: 2007-11-05
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公开(公告)号: US20080207552A1公开(公告)日: 2008-08-28
- 发明人: Yoshiki Sawa , Ryuichi Morishita , Yasufumi Kaneda , Hikaru Matsuda , Toshiki Yoshimine
- 申请人: Yoshiki Sawa , Ryuichi Morishita , Yasufumi Kaneda , Hikaru Matsuda , Toshiki Yoshimine
- 申请人地址: JP Osaka
- 专利权人: AnGES MG, Inc.
- 当前专利权人: AnGES MG, Inc.
- 当前专利权人地址: JP Osaka
- 主分类号: A61K31/7088
- IPC分类号: A61K31/7088 ; A61P9/10
摘要:
The present invention provides introduction of NF-κB decoy oligodeoxynucleotide into rat cranial nerve through a carotid artery during global brain ischemia. Polymerase chain reaction demonstrated that one hour after global brain ischemia, transfected NF-κB decoy oligodeoxynucleotide effectively suppressed expression of tumor necrosis factor α, interleukin 1β and intracellular adhesion molecule 1 messenger RNAs. Terminal deoxynucleotidyl transferase-mediated deoxyuridine nick-end labeling staining and immunohistochemistry using microtubule-associated protein 2 demonstrated that transfected NF-κB decoy oligodeoxynucleotide significantly attenuated neuronal damage seven days after global brain ischemia. Therapeutic transfection of NF-κB decoy oligodeoxynucleotide during brain ischemia may be effective for attenuation of neuronal damage, suggesting a strategy for protecting the cerebrum from global ischemia.