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14 条记录 (耗时 0.021 秒)

    Three-dimentional tissue structure
    1.
    发明申请
    Three-dimentional tissue structure 有权
    三维组织结构

    公开(公告)号：US20070092492A1

    公开(公告)日：2007-04-26

    申请号：US10567728

    申请日：2004-02-02

    申请人： Hikaru Matsuda ,  Yoshiki Sawa ,  Satoshi Taketani ,  Shigeru Miyagawa

    发明人： Hikaru Matsuda ,  Yoshiki Sawa ,  Satoshi Taketani ,  Shigeru Miyagawa

    IPC分类号： A61K35/34 ,  C12N5/06 ,  C12N5/08

    CPC分类号： C12N5/0658 ,  A61K35/12 ,  A61K35/34 ,  A61L27/3804 ,  A61L27/3834 ,  A61L27/3839 ,  A61L27/3895 ,  A61L2430/20 ,  C12N5/0068 ,  C12N5/0657 ,  C12N2506/02 ,  C12N2506/1392 ,  C12N2513/00 ,  C12N2523/00 ,  C12N2533/40 ,  C12N2539/10

    摘要： The present invention provides a prosthetic tissue or sheet capable of withstanding implantation operations, which can be used in actual operation and can be produced by culture. The present invention also provides a novel therapy which can substitute for cell therapy. Particularly, the present invention provides a method for producing a prosthetic tissue comprising a cell derived from a part other than myocardium and capable of withstanding implantation operation. The above-described objects of the present invention were partially achieved by finding that by culturing cells under specific culture conditions, the cells are unexpectedly organized into a tissue, and the resultant prosthetic tissue is capable of being detached from culture dishes. The present invention also provides a three-dimensional structure applicable to heart, comprising a cell derived from a part other than the myocardium of an adult.

    摘要翻译： 本发明提供能够承受植入操作的假体组织或片材，其可以在实际操作中使用并且可以通过培养产生。 本发明还提供了可代替细胞治疗的新型治疗方法。 特别地，本发明提供了一种用于制造假体组织的方法，所述假体组织包含源于除了心肌之外的部分的细胞并且能够承受植入操作。 通过发现通过在特定培养条件下培养细胞，细胞意外地组织成组织，并且所得到的假体组织能够从培养皿中分离，部分实现了本发明的上述目的。 本发明还提供了适用于心脏的三维结构，其包含源自成人心肌之外的部分的细胞。

    Decoy compositions for treating and preventing brain diseases and disorders
    3.
    发明申请
    Decoy compositions for treating and preventing brain diseases and disorders 审中-公开
    用于治疗和预防脑部疾病和疾病的诱饵组合物

    公开(公告)号：US20060135449A1

    公开(公告)日：2006-06-22

    申请号：US10509799

    申请日：2002-03-29

    申请人： Yoshiki Sawa ,  Ryuichi Morishita ,  Yasufumi Kaneda ,  Hikaru Matsuda ,  Toshiki Yoshimine

    发明人： Yoshiki Sawa ,  Ryuichi Morishita ,  Yasufumi Kaneda ,  Hikaru Matsuda ,  Toshiki Yoshimine

    IPC分类号： A61K48/00 ,  A61K9/127

    CPC分类号： A61K9/0019 ,  A61K9/127 ,  A61K31/711 ,  A61K48/005 ,  A61K48/0075 ,  C07K14/4705 ,  C12N15/1131 ,  C12N15/115 ,  C12N15/86 ,  C12N2310/13 ,  C12N2310/315 ,  C12N2760/18811

    摘要： The present invention provides introduction of NF-κB decoy oligodeoxynucleotide into rat cranial nerve through a carotid artery during global brain ischemia. Polymerase chain reaction demonstrated that one hour after global brain ischemia, transfected NF-κB decoy oligodeoxynucleotide effectively suppressed expression of tumor necrosis factor α, interleukin 1β and intracellular adhesion molecule 1 messenger RNAs. Terminal deoxynucleotidyl transferase-mediated deoxyuridine nick-end labeling staining and immunohistochemistry using microtubule-associated protein 2 demonstrated that transfected NF-κB decoy oligodeoxynucleotide significantly attenuated neuronal damage seven days after global brain ischemia. Therapeutic transfection of NF-κB decoy oligodeoxynucleotide during brain ischemia may be effective for attenuation of neuronal damage, suggesting a strategy for protecting the cerebrum from global ischemia.

    摘要翻译： 本发明提供了在全脑缺血期间通过颈动脉将NF-κB诱饵寡脱氧核苷酸引入大鼠颅神经中。 聚合酶链反应表明，全球脑缺血后1小时，转染的NF-κB诱饵寡脱氧核苷酸有效抑制肿瘤坏死因子α，白细胞介素1β和细胞内粘附分子1信使RNA的表达。 末端脱氧核苷酸转移酶介导的脱氧尿苷切口标记染色和使用微管相关蛋白2的免疫组织化学证实，转染的NF-κB诱饵寡脱氧核苷酸在全脑缺血后7天显着减弱神经元损伤。 在脑缺血期间，NF-κB诱饵寡脱氧核苷酸的治疗转染对于减少神经元损伤可能是有效的，这表明保护大脑免受全身缺血的策略。

    Solid state imaging device with adaptive pixel correction
    9.
    发明授权
    Solid state imaging device with adaptive pixel correction 失效
    具有自适应像素校正的固态成像装置

    公开(公告)号：US4858013A

    公开(公告)日：1989-08-15

    申请号：US199161

    申请日：1988-05-26

    申请人： Hikaru Matsuda

    发明人： Hikaru Matsuda

    IPC分类号： H04N5/367

    CPC分类号： H04N5/3675

    摘要： A solid state imaging device is disclosed which includes a solid state sensor for converting an external scene into electrical signals, an A/D converter for converting output signals from the solid state sensor into digital signals, a frame memory for storing offset signals of the solid state sensor, and an arithmetic unit for subtracting the offset signals stored in the frame memory from the digital signals of the A/D converter. The signals from the arithmetic unit are output through a D/A converter and a synchronization adding circuit. In the thus constituted solid state imaging device, a judgement as to the level of the offset signal from the frame memory is made. If this level is outside a predetermined range, it is judged that there is a defective pixel. Interpolation is then effected with neighboring pixel signals in a spatial processor.

    摘要翻译： 公开了一种固态成像装置，其包括用于将外部场景转换为电信号的固态传感器，用于将来自固态传感器的输出信号转换为数字信号的A / D转换器，用于存储固体的偏移信号的帧存储器 状态传感器和用于从A / D转换器的数字信号中减去存储在帧存储器中的偏移信号的算术单元。 来自算术单元的信号通过D / A转换器和同步加法电路输出。 在这样构成的固态成像装置中，作出关于来自帧存储器的偏移信号的电平的判断。 如果该级别在预定范围之外，则判断为存在缺陷像素。 然后用空间处理器中的相邻像素信号进行插值。

    Three-dimensional tissue structure
    10.
    发明授权
    Three-dimensional tissue structure 有权
    三维组织结构

    公开(公告)号：US09587222B2

    公开(公告)日：2017-03-07

    申请号：US10567728

    申请日：2004-02-02

    申请人： Hikaru Matsuda ,  Yoshiki Sawa ,  Satoshi Taketani ,  Shigeru Miyagawa

    发明人： Hikaru Matsuda ,  Yoshiki Sawa ,  Satoshi Taketani ,  Shigeru Miyagawa

    IPC分类号： C12N15/00 ,  C12N5/00 ,  C12N5/02 ,  C12N5/071 ,  C12N5/077 ,  A61L27/38 ,  A61K35/34 ,  A61K35/12

    CPC分类号： C12N5/0658 ,  A61K35/12 ,  A61K35/34 ,  A61L27/3804 ,  A61L27/3834 ,  A61L27/3839 ,  A61L27/3895 ,  A61L2430/20 ,  C12N5/0068 ,  C12N5/0657 ,  C12N2506/02 ,  C12N2506/1392 ,  C12N2513/00 ,  C12N2523/00 ,  C12N2533/40 ,  C12N2539/10

    摘要： The present invention provides a prosthetic tissue or sheet capable of withstanding implantation operations, which can be used in actual operation and can be produced by culture. The present invention also provides a novel therapy which can substitute for cell therapy. Particularly, the present invention provides a method for producing a prosthetic tissue comprising a cell derived from a part other than myocardium and capable of withstanding implantation operation. The above-described objects of the present invention were partially achieved by finding that by culturing cells under specific culture conditions, the cells are unexpectedly organized into a tissue, and the resultant prosthetic tissue is capable of being detached from culture dishes. The present invention also provides a three-dimensional structure applicable to heart, comprising a cell derived from a part other than the myocardium of an adult.

    摘要翻译： 本发明提供能够承受植入操作的假体组织或片材，其可以在实际操作中使用并且可以通过培养产生。 本发明还提供了可代替细胞治疗的新型治疗方法。 特别地，本发明提供了一种用于制造假体组织的方法，所述假体组织包含源于除了心肌之外的部分的细胞并且能够承受植入操作。 通过发现通过在特定培养条件下培养细胞，细胞意外地组织成组织，并且所得到的假体组织能够从培养皿中分离，部分实现了本发明的上述目的。 本发明还提供了适用于心脏的三维结构，其包含源自成人心肌之外的部分的细胞。