发明申请
- 专利标题： Tricyclic Anilide Spirolactam Cgrp Receptor Antagonists
- 专利标题（中）： 三环酰苯胺内酰胺Cgrp受体拮抗剂
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申请号： US11662246申请日： 2005-09-06
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公开(公告)号： US20080214511A1公开(公告)日： 2008-09-04
- 发明人: Ian M. Bell , Steven N. Gallicchiro , Craig A. Stump , Cory R. Theberge , Joseph P. Vacca , C. Blair Zartman , Xufang Zhang
- 申请人： Ian M. Bell , Steven N. Gallicchiro , Craig A. Stump , Cory R. Theberge , Joseph P. Vacca , C. Blair Zartman , Xufang Zhang
- 申请人地址： US NJ Rahway
- 专利权人： MERCK & CO., INC.
- 当前专利权人： MERCK & CO., INC.
- 当前专利权人地址： US NJ Rahway
- 国际申请： PCT/US05/31617 WO 20050906
- 主分类号： A61K31/437
- IPC分类号： A61K31/437 ; C07D471/06 ; C07D487/06 ; A61P25/00 ; A61K31/55 ; A61K31/53 ; A61K31/4985 ; A61K31/616 ; A61K31/5415
摘要：
The present invention is directed to compounds of Formula I: I (where A1, A2, B1, B2, B3, B4, D1, D2, J, K, T, U, V, W, X, Y, Z, R4, R5a, R5b, R5c, m and n are defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
公开/授权文献
- US07696192B2 Tricyclic anilide spirolactam CGRP receptor antagonists 公开/授权日：2010-04-13
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