-
公开(公告)号：US08133891B2
公开(公告)日：2012-03-13
申请号：US12718386
申请日：2010-03-05
申请人： Ian M. Bell , Steven N. Gallicchio , Craig A. Stump , Cory R. Theberge , Joseph P. Vacca , C. Blair Zartman , Xufang Zhang
发明人： Ian M. Bell , Steven N. Gallicchio , Craig A. Stump , Cory R. Theberge , Joseph P. Vacca , C. Blair Zartman , Xufang Zhang
IPC分类号： A01N43/58 , A01N43/60 , A61K31/50 , A61K31/495
CPC分类号： C07D519/00 , C07D209/96 , C07D471/06 , C07D471/16 , C07D487/06
摘要： The present invention is directed to compounds of Formula I: I (where A1, A2, B1, B2, B3, B4, D1, D2, J, K, T, U, V, W, X, Y, Z, R4, R5a, R5b, R5c, m and n are defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及式I化合物：其中A1，A2，B1，B2，B3，B4，D1，D2，J，K，T，U，V，W，X，Y，Z， R5a，R5b，R5c，m和n在本文中定义），其可用作CGRP受体的拮抗剂，并且可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
-
公开(公告)号：US20060189577A1
公开(公告)日：2006-08-24
申请号：US10564347
申请日：2004-07-20
申请人： Annette Kim , Xufang Zhang
发明人： Annette Kim , Xufang Zhang
IPC分类号： A61K31/4439 , A61K31/695 , A61K31/4192 , A61K31/4025 , A61K31/401
CPC分类号： C07D401/04 , A61K31/40 , A61K45/06 , C07D207/34 , C07D207/456 , C07D401/06 , C07D403/06 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , A61K2300/00
摘要： The present invention relates to compounds that are capable of inhibiting, modulating and/or regulating signal transduction of both receptor-type and non-receptor type tyrosine kinases. The compounds of the instant invention possess a core structure that comprises a substituted pyrrole moiety. The present invention is also related to the pharmaceutically acceptable salts, hydrates and stereoisomers of these compounds.
-
公开(公告)号：US08003792B2
公开(公告)日：2011-08-23
申请号：US11662703
申请日：2005-09-09
申请人： Ian M. Bell , Cory R. Theberge , Craig A. Stump , Xufang Zhang , Steven N. Gallicchio , C. Blair Zartman
发明人： Ian M. Bell , Cory R. Theberge , Craig A. Stump , Xufang Zhang , Steven N. Gallicchio , C. Blair Zartman
IPC分类号： A61K31/40 , A61K31/438 , C07D401/04 , C07D227/02
CPC分类号： C07D401/14 , C07D403/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D519/00 , Y02P20/582
摘要： The present invention is directed to compounds of Formula I: (where variables A1, A2, B, J, K, m, n, R4, R5a, R5b and R5c are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及式I化合物（其中变量A1，A2，B，J，K，m，n，R4，R5a，R5b和R5c如本文所定义）可用作CGRP受体的拮抗剂，并且可用于 治疗或预防CGRP涉及的疾病，如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
-
公开(公告)号：US07750010B2
公开(公告)日：2010-07-06
申请号：US11662702
申请日：2005-09-09
IPC分类号： C07D401/12 , C07D403/12 , A61K31/519 , A61K31/4166 , A61P25/06
CPC分类号： C07D487/06 , C07D471/06
摘要： The present invention is directed to compounds of Formula I: I (where A1, A2, B1, B2, B3, B4, D1, D2, T, U, V, W, X, Y, Z, R4, R5a?, R5b, R5c, R6, m and n are defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及式I化合物：其中A1，A2，B1，B2，B3，B4，D1，D2，T，U，V，W，X，Y，Z，R4，R5a，R5b ，R 5，R 6，m和n如本文所定义）可用作CGRP受体的拮抗剂，可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
-
公开(公告)号：US07696192B2
公开(公告)日：2010-04-13
申请号：US11662246
申请日：2005-09-06
申请人： Ian M. Bell , Steven N. Gallicchio , Craig A. Stump , Cory R. Theberge , Joseph P. Vacca , C. Blair Zartman , Xufang Zhang
发明人： Ian M. Bell , Steven N. Gallicchio , Craig A. Stump , Cory R. Theberge , Joseph P. Vacca , C. Blair Zartman , Xufang Zhang
IPC分类号： A61K31/554
CPC分类号： C07D519/00 , C07D209/96 , C07D471/06 , C07D471/16 , C07D487/06
摘要： The present invention is directed to compounds of Formula I: I (where A1, A2, B1, B2, B3, B4, D1, D2, J, K, T, U, V, W, X, Y, Z, R4, R5a, R5b, R5c, m and n are defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及式I化合物：其中A1，A2，B1，B2，B3，B4，D1，D2，J，K，T，U，V，W，X，Y，Z， R5a，R5b，R5c，m和n在本文中定义），其可用作CGRP受体的拮抗剂，并且可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
-
6.发明申请IMMUNOGENIC COMPOSITIONS FOR GRAM POSITIVE BACTERIA SUCH AS STREPTOCOCCUS AGALACTIAE 有权AM AM E E E E E E E E E E E E E E E E E E E E E E E公开(公告)号：US20090221535A1
公开(公告)日：2009-09-03
申请号：US11662702
申请日：2005-09-09
IPC分类号： A61K31/60 , C07D487/06 , A61K31/4985 , A61K31/551 , A61P25/00 , A61K31/47 , A61K31/535
CPC分类号： C07D487/06 , C07D471/06
摘要： The present invention is directed to compounds of Formula I: I (where A1, A2, B1, B2, B3, B4, D1, D2, T, U, V, W, X, Y, Z. R4, R5a?, R5b, R5c, R6, m and n are defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及式I化合物：其中A1，A2，B1，B2，B3，B4，D1，D2，T，U，V，W，X，Y，Z.R4，R5a，R5b ，R 5，R 6，m和n如本文所定义），其可用作CGRP受体的拮抗剂，并且可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
-
公开(公告)号：US07504429B2
公开(公告)日：2009-03-17
申请号：US10564347
申请日：2004-07-20
申请人： Annette S. Kim , Xufang Zhang
发明人： Annette S. Kim , Xufang Zhang
IPC分类号： A61K31/40 , C07D405/00
CPC分类号： C07D401/04 , A61K31/40 , A61K45/06 , C07D207/34 , C07D207/456 , C07D401/06 , C07D403/06 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , A61K2300/00
摘要： The present invention relates to compounds that are capable of inhibiting, modulating and/or regulating signal transduction of both receptor-type and non-receptor type tyrosine kinases. The compounds of the instant invention possess a core structure that comprises a substituted pyrrole moiety. The present invention is also related to the pharmaceutically acceptable salts, hydrates and stereoisomers of these compounds.
-
公开(公告)号：US20080214511A1
公开(公告)日：2008-09-04
申请号：US11662246
申请日：2005-09-06
申请人： Ian M. Bell , Steven N. Gallicchiro , Craig A. Stump , Cory R. Theberge , Joseph P. Vacca , C. Blair Zartman , Xufang Zhang
发明人： Ian M. Bell , Steven N. Gallicchiro , Craig A. Stump , Cory R. Theberge , Joseph P. Vacca , C. Blair Zartman , Xufang Zhang
IPC分类号： A61K31/437 , C07D471/06 , C07D487/06 , A61P25/00 , A61K31/55 , A61K31/53 , A61K31/4985 , A61K31/616 , A61K31/5415
CPC分类号： C07D519/00 , C07D209/96 , C07D471/06 , C07D471/16 , C07D487/06
摘要： The present invention is directed to compounds of Formula I: I (where A1, A2, B1, B2, B3, B4, D1, D2, J, K, T, U, V, W, X, Y, Z, R4, R5a, R5b, R5c, m and n are defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及式I化合物：其中A 1，A 2，B 1，B 2， B，S 4，B 4，D 1，D 2，J，K，T， U，V，W，X，Y，Z，R 4，R 5a，R 5b，R 5c， >，m和n在本文中定义）可用作CGRP受体的拮抗剂并且可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
-
公开(公告)号：US20080096878A1
公开(公告)日：2008-04-24
申请号：US11662703
申请日：2005-09-09
申请人： Ian Bell , Cory Theberge , Craig Stump , Xufang Zhang , Steven Gallicchio , C.Blair Zartman
发明人： Ian Bell , Cory Theberge , Craig Stump , Xufang Zhang , Steven Gallicchio , C.Blair Zartman
IPC分类号： A61K31/535 , A61K31/4015 , A61K31/427 , A61P25/00 , C07D209/96 , C07D417/14 , C07D401/14 , A61P25/06 , A61K31/4402 , A61K31/501
CPC分类号： C07D401/14 , C07D403/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D519/00 , Y02P20/582
摘要： The present invention is directed to compounds of Formula (I): (where variables A1, A2, B, J, K, m, n, R4, R5a, R5b and R5c are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及式（I）的化合物：其中变量A 1，A 2，B，J，K，m，n，R“ 4，R 5a，R 5b和R 5c如本文所定义）可用作CGRP受体的拮抗剂，并且可用于 治疗或预防CGRP涉及的疾病，如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
-
10.发明申请公开(公告)号：US20100160334A1
公开(公告)日：2010-06-24
申请号：US12718386
申请日：2010-03-05
申请人： Ian M. Bell , Steven N. Gallicchio , Graig A. Stump , Cory R. Theberge , Joseph P. Vacca , C. Blair Zartman , Xufang Zhang
发明人： Ian M. Bell , Steven N. Gallicchio , Graig A. Stump , Cory R. Theberge , Joseph P. Vacca , C. Blair Zartman , Xufang Zhang
IPC分类号： A61K31/4985 , C07D471/16 , A61P25/06
CPC分类号： C07D519/00 , C07D209/96 , C07D471/06 , C07D471/16 , C07D487/06
摘要： The present invention is directed to compounds of Formula I: I (where A1, A2, B1, B2, B3, B4, D1, D2, J, K, T, U, V, W, X, Y, Z, R4, R5a, R5b, R5c, m and n are defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及式I化合物：其中A1，A2，B1，B2，B3，B4，D1，D2，J，K，T，U，V，W，X，Y，Z， R5a，R5b，R5c，m和n在本文中定义），其可用作CGRP受体的拮抗剂，并且可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
-
-
-
-
-
-
-
-
-
搜索结果
10 条记录 (耗时 0.023 秒)
