发明申请
US20080221217A1 Phenyl Compounds and Their Use in the Treatment of Type II Diabetes
有权
苯基化合物及其在II型糖尿病治疗中的应用
- 专利标题： Phenyl Compounds and Their Use in the Treatment of Type II Diabetes
- 专利标题（中）： 苯基化合物及其在II型糖尿病治疗中的应用
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申请号： US11996123申请日： 2006-07-14
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公开(公告)号： US20080221217A1公开(公告)日： 2008-09-11
- 发明人: Larry Chris Blaszczak , Shon Roland Pulley , Michael Alan Robertson , Scott Martin Sheehan , Qing Shi , Brian Morgan Watson , Michael Robert Wiley
- 申请人： Larry Chris Blaszczak , Shon Roland Pulley , Michael Alan Robertson , Scott Martin Sheehan , Qing Shi , Brian Morgan Watson , Michael Robert Wiley
- 国际申请： PCT/US06/27673 WO 20060714
- 主分类号： A61K31/166
- IPC分类号： A61K31/166 ; C07C233/65 ; A61K31/155 ; A61P3/00
摘要：
The present invention is directed to compounds of formula (I) or a pharmaceutically acceptable salt thereof; wherein A is (xx); X is selected from CH, CF and N, R5 is selected from H, C1-C6 alkyl, C1-C6 fluoroalkyl, and —OR12, R9 is selected from H and —C(O)NR1OR11, R12 is selected from H, C1-C6 alkyl and C3-C6 cycloalkyl for use as inhibitors of the DPP-IV enzyme in the treatment or prevention of conditions including Type II diabetes.
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