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33 条记录 (耗时 0.057 秒)

    1-amino linked compounds
    6.
    发明授权
    1-amino linked compounds 有权
    1-氨基连接的化合物

    公开(公告)号：US08106090B2

    公开(公告)日：2012-01-31

    申请号：US11996128

    申请日：2006-07-14

    申请人： Larry Chris Blaszczak ,  Shon Roland Pulley ,  Michael Alan Robertson ,  Scott Martin Sheehan ,  Qing Shi ,  Michael Robert Wiley

    发明人： Larry Chris Blaszczak ,  Shon Roland Pulley ,  Michael Alan Robertson ,  Scott Martin Sheehan ,  Qing Shi ,  Michael Robert Wiley

    IPC分类号： C07D207/04 ,  A61K31/40

    CPC分类号： C07C311/05 ,  C07C215/28 ,  C07C233/36 ,  C07C233/78 ,  C07D207/06 ,  C07D207/08 ,  C07D207/16 ,  C07D209/44 ,  C07D211/26 ,  C07D217/04 ,  C07D231/12 ,  C07D233/54 ,  C07D235/06 ,  C07D249/04 ,  C07D249/18 ,  C07D295/13 ,  C07D487/04

    摘要： The present invention is directed to compounds of formula (I): or a pharmaceutically acceptable salt thereof; wherein A is (II); X is selected from CH, CF and N, R8 is selected from H, C1-C6 alkyl, aryl, heteroaryl, C1-C6 alkylaryl, C1-C6 alkylheteroaryl, C2-C6 alkyl-O—C1-C6 alkyl, C1-C6 haloalkyl, hydroxy C2-C6 alkyl, —C(O)R9 and —SO2R9, or R7 and R8 combine to form (III), (IV); W is selected from CR1O and CR15, R1O is selected from H, halo, —C(O)NR13R14, C1-C6 alkyl, aryl, heteroaryl, C1-C6 alkylaryl, C1-C6 alkylheteroaryl, C1-C6 alkyl-O—C1-C6 alkyl and hydroxy C1-C6 alkyl; Het is a N-linked 5-membered heteroaryl ring optionally substituted with 1-3 substituents selected from methoxy, Cl, F, CH3, CF3, aryl, heteroaryl, C1-C4 alkylaryl or C1-C4 alkylheteroaryl, for use as inhibitors of the DPP-IV enzyme in the treatment or prevention of conditions including Type II diabetes.

    摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐; 其中A为（II）; X选自CH，CF和N，R8选自H，C1-C6烷基，芳基，杂芳基，C1-C6烷基芳基，C1-C6烷基杂芳基，C2-C6烷基-O-C1-C6烷基，C1-C6 卤代烷基，羟基C 2 -C 6烷基，-C（O）R 9和-SO 2 R 9，或R 7和R 8结合形成（III），（IV）; W选自CR1O和CR15，R1O选自H，卤素，-C（O）NR13R14，C1-C6烷基，芳基，杂芳基，C1-C6烷基芳基，C1-C6烷基杂芳基，C1-C6烷基-O-C1 -C 1-6烷基和羟基C 1 -C 6烷基; Het是任选被1-3个选自甲氧基，Cl，F，CH 3，CF 3，芳基，杂芳基，C 1 -C 4烷基芳基或C 1 -C 4烷基杂芳基的取代基取代的N-连接的5元杂芳基环，用作 DPP-IV酶在治疗或预防包括II型糖尿病的病症中。