The arrangement of a charge air cooler in an intake system of an internal combustion engine has a charge air cooler that on the one hand is supplied with combustion air and on the other hand with a liquid coolant. A coolant/air cooler is provided in which the liquid coolant is cooled by an air stream. The charge air cooler is slantedly arranged in a pipe conduit for the charge air with regard to the end face of a heat exchanger block exposed to the charge air. The end face of the charge air cooler is arranged relative to the cross-section of the pipe conduit at an angle of >45°.