发明申请
US20080227781A1 IMIDAZOLE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS
有权
用于治疗神经损伤性疾病的咪唑化合物
- 专利标题： IMIDAZOLE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS
- 专利标题（中）： 用于治疗神经损伤性疾病的咪唑化合物
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申请号： US11971272申请日： 2008-01-09
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公开(公告)号： US20080227781A1公开(公告)日： 2008-09-18
- 发明人: Michael A. Brodney , Karen J. Coffman
- 申请人： Michael A. Brodney , Karen J. Coffman
- 专利权人： Pfizer Inc.
- 当前专利权人： Pfizer Inc.
- 主分类号： A61K31/5377
- IPC分类号： A61K31/5377 ; A61K31/454 ; A61K31/4178 ; A61K31/4172 ; C07D413/02 ; A61P25/28
摘要：
The present invention relates to compounds of the Formula I wherein R1, R2, R3, R4, R6, R7 and A are as defined. Compounds of the Formula I have activity inhibiting production of Aβ-peptide. The invention also relates to pharmaceutical compositions and methods for treating diseases and disorders, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of the Formula I.
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