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US20080242676A1 PYRROLE DERIVATIVES AS ANTIMYCOBACTERIAL COMPOUNDS 失效
吡咯衍生物作为抗微生物化合物

PYRROLE DERIVATIVES AS ANTIMYCOBACTERIAL COMPOUNDS
Abstract:
Novel pyrrole derivatives of formula (I) and their pharmaceutically acceptable acid addition salts having superior antimycobacterial activity against clinically sensitive as well as resistant strains of Mycobacterium tuberculosis as well as having lesser toxicity compared to known compounds. The use of the novel compounds of formula (I) for treatment of latent tuberculosis including Multi Drug Resistant Tuberculosis (MDR TB). The methods for preparation of the novel compounds, pharmaceutical compositions containing the novel compounds and method of treating MDR TB by administration of compounds of formula (I).
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