Invention Application
US20080249129A1 Compositions and Methods for Treatment of Protein Misfolding Diseases
审中-公开
用于治疗蛋白质错折叠疾病的组合物和方法
- Patent Title: Compositions and Methods for Treatment of Protein Misfolding Diseases
- Patent Title (中): 用于治疗蛋白质错折叠疾病的组合物和方法
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Application No.: US10599513Application Date: 2005-04-04
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Publication No.: US20080249129A1Publication Date: 2008-10-09
- Inventor: Susan L. Lindquist , Tiago Outeiro
- Applicant: Susan L. Lindquist , Tiago Outeiro
- Applicant Address: US MA Cambridge
- Assignee: Whitehead Institute for Biomedical Research
- Current Assignee: Whitehead Institute for Biomedical Research
- Current Assignee Address: US MA Cambridge
- International Application: PCT/US2005/011242 WO 20050404
- Main IPC: A61K31/47
- IPC: A61K31/47 ; C12N15/00 ; C12Q1/02 ; C12Q1/68
Abstract:
Disclosed are compounds and conditions that either suppress or enhance toxicity in yeast cells expressing alpha synuclein or huntingtin. These compounds and conditions can be used in the development of compositions that suppress toxicity, fibril formation, and/or diseases mediated at least in part by alpha synuclein or huntingtin.
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