发明申请
US20080254128A1 Process for the precipitation and isolation of 6,6-dimethyl-3-aza-bicyclo [3.1.0] hexane-amide compounds by controlled precipitation and pharmaceutical formulations containing same
失效
通过控制沉淀沉淀和分离6,6-二甲基-3-氮杂 - 双环[3.1.0]己烷 - 酰胺化合物的方法和含有其的药物制剂
![Process for the precipitation and isolation of 6,6-dimethyl-3-aza-bicyclo [3.1.0] hexane-amide compounds by controlled precipitation and pharmaceutical formulations containing same](/docs/US/2008-10-16/US20080254128A1/abs.jpg.600x600.jpg)
- 专利标题： Process for the precipitation and isolation of 6,6-dimethyl-3-aza-bicyclo [3.1.0] hexane-amide compounds by controlled precipitation and pharmaceutical formulations containing same
- 专利标题（中）： 通过控制沉淀沉淀和分离6,6-二甲基-3-氮杂 - 双环[3.1.0]己烷 - 酰胺化合物的方法和含有其的药物制剂
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申请号： US12080989申请日： 2008-04-08
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公开(公告)号： US20080254128A1公开(公告)日： 2008-10-16
- 发明人: Dimitrios Zarkadas , Vincenzo Liotta , Christopher Stanley Pridgen , Wing-kee Philip Cho , Zhihui Qiu
- 申请人： Dimitrios Zarkadas , Vincenzo Liotta , Christopher Stanley Pridgen , Wing-kee Philip Cho , Zhihui Qiu
- 主分类号： A61K9/16
- IPC分类号： A61K9/16 ; C07D209/52 ; A61K31/403
![Process for the precipitation and isolation of 6,6-dimethyl-3-aza-bicyclo [3.1.0] hexane-amide compounds by controlled precipitation and pharmaceutical formulations containing same](/abs-image/US/2008/10/16/US20080254128A1/abs.jpg.150x150.jpg)
摘要：
The present invention provides a method of continuous precipitation and isolation of an amorphous solid particulate form of 3-[2-(3-tert-Butyl-ureido)-3,3-dimethyl-butyryl]-6,6-dimethyl-3-aza-bicyclo[3.1.0]hexane-2-carboxylic acid (2-carbamoyl-1-cyclobutylmethyl-2-oxo-ethyl)-amide having controlled physical properties. The present invention provides also pharmaceutical formulations comprising the precipitated compound.
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