发明申请
- 专利标题： Collagen Receptor I-Domain Binding Modulators
- 专利标题（中）： 胶原受体I结构域结合调节剂
-
申请号： US12066955申请日： 2004-09-15
-
公开(公告)号： US20080255028A1公开(公告)日： 2008-10-16
- 发明人: Jyrki Heino , Mark Johnson , Jarmo Kapyla , Anne Marjamaki , Tommi Nyronen , Marika Ojala , Olli Pentikainen , Liisa Nissinen
- 申请人： Jyrki Heino , Mark Johnson , Jarmo Kapyla , Anne Marjamaki , Tommi Nyronen , Marika Ojala , Olli Pentikainen , Liisa Nissinen
- 申请人地址： FI Turku
- 专利权人： Biotie Therapies Corporation
- 当前专利权人： Biotie Therapies Corporation
- 当前专利权人地址： FI Turku
- 优先权： FI20055496 20050916
- 国际申请： PCT/FI06/50396 WO 20040915
- 主分类号： A61K38/02
- IPC分类号： A61K38/02 ; G06G7/60 ; A61P29/00 ; A61P7/02 ; A61P35/00
摘要：
The present invention relates to a refined and detailed molecular model of the α2⊕1 integrin I-domain, especially the MIDAS and to the use of such a model for designing novel integrin modulators, especially α2β1 integrin modulators. The present invention further relates to novel α2β1 I-domain modulators, which are of therapeutic potential. The present invention further relates to specific families of small molecule modulators interacting with collagen receptors, tetracyclic polyketides and sulfonamides. The present invention further relates to the use of such modulators for the manufacture of medicaments for thrombosis, inflammation and/or cancer
公开/授权文献
- US20090286713A9 Collagen Receptor I-Domain Binding Modulators 公开/授权日：2009-11-19
信息查询
IPC分类:
