发明申请
US20080255112A1 Pyrimidine-Substituted Benzimidazole Derivatives as Protein Kinase Inhibitors
失效
嘧啶取代的苯并咪唑衍生物作为蛋白激酶抑制剂
- 专利标题： Pyrimidine-Substituted Benzimidazole Derivatives as Protein Kinase Inhibitors
- 专利标题（中）： 嘧啶取代的苯并咪唑衍生物作为蛋白激酶抑制剂
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申请号： US11915148申请日： 2006-06-30
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公开(公告)号： US20080255112A1公开(公告)日： 2008-10-16
- 发明人: Guobao Zhang , Pingda Ren , Xia Wang , Nathanael Gray , Taebo Sim
- 申请人： Guobao Zhang , Pingda Ren , Xia Wang , Nathanael Gray , Taebo Sim
- 国际申请： PCT/US2006/025706 WO 20060630
- 主分类号： A61K31/5377
- IPC分类号： A61K31/5377 ; C07D403/14 ; C07D413/14 ; A61K31/506
摘要：
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of Alk, Abl, BRK, Blk, BMX, CSK, c-Src, c-Raf, EGFR, Fes, FGFR3, Fms, Fyn, IGF-IR, IR, IKKα, IKKβ, JAK2, JAK3, KDR, Lck, Met, p70S6k, Ros, Rsk1, SAPK2α, SAPK2β, SAPK3, SIK, Tie2, TrkB and/or WNK3 kinases.
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