发明申请
- 专利标题: Quinoline Derivatives as Antibacterial Agents
- 专利标题(中): 喹啉衍生物作为抗菌剂
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申请号: US11997182申请日: 2006-07-31
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公开(公告)号: US20080255116A1公开(公告)日: 2008-10-16
- 发明人: Koenraad Jozef Lodewijk Marcel Andries , Anil Koul , Jerome Emile Georges Guillemont , Elisabeth Therese Jeanne Pasquier , David Francis Alain Lancois
- 申请人: Koenraad Jozef Lodewijk Marcel Andries , Anil Koul , Jerome Emile Georges Guillemont , Elisabeth Therese Jeanne Pasquier , David Francis Alain Lancois
- 专利权人: JANSSEN PHARMACEUTICA N.V.
- 当前专利权人: JANSSEN PHARMACEUTICA N.V.
- 优先权: EP05107159.5 20050803
- 国际申请: PCT/EP06/64856 WO 20060731
- 主分类号: A61K31/4709
- IPC分类号: A61K31/4709 ; C07D215/20 ; C07D405/02 ; C07D401/04 ; C07D413/04 ; A61P31/04 ; A61K31/5377 ; A61K31/496 ; A61K31/4704
摘要:
Use of a compound for the manufacture of a medicament for the treatment of a bacterial infection provided that the bacterial infection is other than a Mycobacterial infection, said compound being a compound of Formula (Ia) or (Ib) a pharmaceutically acceptable acid or base addition salt thereof, a quaternary amine thereof, a stereochemically isomeric form thereof, a tautomeric form thereof or a N-oxide form thereof, wherein R1 is hydrogen, halo, haloalkyl, cyano, hydroxy, Ar, Het, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl; p is 1, 2 or 3; R2 is hydrogen; alkyl; hydroxy; mercapto; optionally substituted alkyloxy; alkyloxyalkyloxy; alkylthio; mono or di(alkyl)amino wherein alkyl may optionally be substituted; Ar; Het or a radical of formula R3 is alkyl, Ar, Ar-alkyl, Het or Het-alkyl; q is zero, 1, 2, 3 or 4; X is a direct bond or CH2; R4 and R5 each independently are hydrogen, alkyl or benzyl; or R4 and R5 may be taken together including the N to which they are attached; R6 is hydrogen or a radical of formula R7 is hydrogen, alkyl, Ar or Het; R8 is hydrogen or alkyl; R9 is oxo; or R8 and R9 together form the radical —CH═CH—N═;
公开/授权文献
- US08017606B2 Quinoline derivatives as antibacterial agents 公开/授权日:2011-09-13
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