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    METHODS AND COMPOSITIONS RELATING TO STEROID HORMONE RECEPTOR-DEPENDENT PROLIFERATIVE DISORDERS
    4.
    发明公开
    METHODS AND COMPOSITIONS RELATING TO STEROID HORMONE RECEPTOR-DEPENDENT PROLIFERATIVE DISORDERS 审中-公开

    公开(公告)号：US20240245672A1

    公开(公告)日：2024-07-25

    申请号：US18441067

    申请日：2024-02-14

    申请人： Wayne State University

    发明人： Manohar Ratnam

    IPC分类号： A61K31/4704 ,  A61P35/00

    CPC分类号： A61K31/4704 ,  A61P35/00

    摘要： A pharmaceutical composition, comprising a compound having chemical structural formula I:






    where R1 is selected from the group consisting of: an alkyl group, a heteroalkyl group, an aryl group, a heteroaryl group, an alkenyl group, a heteroalkenyl group, an alkynyl group, a heteroalkynyl group, a cycloalkyl group, a hetercycloalkyl group, an alkylcycloalkyl group, a heteroalkyl cycloalkyl group, an aralkyl group, a heteroaralkyl group, an alkoxy group, a polar group, an ester and a charged group; a pharmaceutically acceptable hydrolysable, or enzymatically cleavable, prodrug form thereof; and/or a pharmaceutically acceptable salt thereof;
    where R4′ is H or an alkoxy group; where both R5 and R3′ are OH, and where one or both OH groups is modified as a pharmaceutically acceptable hydrolysable, or enzymatically cleavable, prodrug form thereof, wherein the prodrug form thereof comprises an ester selected from: an amino acid ester, a phosphate ester, and a sulfonate ester.