- 专利标题： NOVEL PHYSIOLOGICALLY ACTIVE SUBSTANCES
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申请号： US11927564申请日： 2007-10-29
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公开(公告)号： US20080255146A1公开(公告)日： 2008-10-16
- 发明人: Yoshihiko KOTAKE , Jun Niijima , Yoshio Fukuda , Mitsuo Nagai , Regina Mikie Kanada , Takashi Nakashima , Masahi Yoshida , Toshio Tsuchida
- 申请人： Yoshihiko KOTAKE , Jun Niijima , Yoshio Fukuda , Mitsuo Nagai , Regina Mikie Kanada , Takashi Nakashima , Masahi Yoshida , Toshio Tsuchida
- 优先权： JP2002-155853 20020529; JP2002-223355 20020731; JP2003-63176 20030310
- 主分类号： A61K31/496
- IPC分类号： A61K31/496 ; C07D313/00 ; A61K31/365 ; A61P19/02 ; A61P29/00 ; A61P35/00 ; A61P9/10 ; C07D405/12
摘要：
The present invention relates to a compound represented by the formula (I): (wherein, R3, R6, R7 and R21 are the same as or different from one another and each represents a hydroxyl group etc.), a pharmacologically acceptable salt thereof or a hydrate of them. The compound (I) of the present invention suppresses angiogenesis, in particular, suppresses VEGF production in a hypoxic condition and is useful as a therapeutic agent for treating solid cancer.
公开/授权文献
- US07893068B2 Physiologically active substances 公开/授权日：2011-02-22