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公开(公告)号:US20080275059A1
公开(公告)日:2008-11-06
申请号:US11927542
申请日:2007-10-29
申请人: Yoshihiko KOTAKE , Jun Niijima , Yoshio Fukuda , Mitsuo Nagai , Regina Mikie Kanada , Takashi Nakashima , Masahi Yoshida , Toshio Tsuchida
发明人: Yoshihiko KOTAKE , Jun Niijima , Yoshio Fukuda , Mitsuo Nagai , Regina Mikie Kanada , Takashi Nakashima , Masahi Yoshida , Toshio Tsuchida
IPC分类号: A61K31/496 , C07D313/00 , C07D405/12 , A61P19/02 , A61P35/04 , A61P29/00 , A61P35/00 , A61P9/10 , A61K31/365
CPC分类号: A61K31/336 , A61K31/366 , A61K31/4025 , A61K31/4427 , A61K31/4523 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/551 , C07D407/06
摘要: The present invention relates to a compound represented by the formula (I): (wherein, R3, R6, R7 and R21 are the same as or different from one another and each represents a hydroxyl group etc.), a pharmacologically acceptable salt thereof or a hydrate of them. The compound (I) of the present invention suppresses angiogenesis, in particular, suppresses VEGF production in a hypoxic condition and is useful as a therapeutic agent for treating solid cancer.
摘要翻译: 本发明涉及由式(I)表示的化合物:其中R 3,R 6,R 7和R 7, SUP> 21个彼此相同或不同,各自表示羟基等),其药理学上可接受的盐或它们的水合物。 本发明的化合物(I)抑制血管生成,特别是在缺氧条件下抑制VEGF的产生,可用作治疗实体癌的治疗剂。
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公开(公告)号:US07619100B2
公开(公告)日:2009-11-17
申请号:US11927542
申请日:2007-10-29
申请人: Yoshihiko Kotake , Jun Niijima , Yoshio Fukuda , Mitsuo Nagai , Regina Mikie Kanada , Takashi Nakashima , Masahi Yoshida , Toshio Tsuchida
发明人: Yoshihiko Kotake , Jun Niijima , Yoshio Fukuda , Mitsuo Nagai , Regina Mikie Kanada , Takashi Nakashima , Masahi Yoshida , Toshio Tsuchida
IPC分类号: C07D313/00 , C07D313/04
CPC分类号: A61K31/336 , A61K31/366 , A61K31/4025 , A61K31/4427 , A61K31/4523 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/551 , C07D407/06
摘要: The present invention relates to a compound represented by the formula (I): (wherein, R3, R6, R7 and R21 are the same as or different from one another and each represents a hydroxyl group etc.), a pharmacologically acceptable salt thereof or a hydrate of them. The compound (I) of the present invention suppresses angiogenesis, in particular, suppresses VEGF production in a hypoxic condition and is useful as a therapeutic agent for treating solid cancer.
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公开(公告)号:US07550503B2
公开(公告)日:2009-06-23
申请号:US11473201
申请日:2006-06-23
申请人: Yoshihiko Kotake , Jun Niijima , Yoshio Fukuda , Mitsuo Nagai , Regina Mikie Kanada , Takashi Nakashima , Masahi Yoshida , Toshio Tsuchida
发明人: Yoshihiko Kotake , Jun Niijima , Yoshio Fukuda , Mitsuo Nagai , Regina Mikie Kanada , Takashi Nakashima , Masahi Yoshida , Toshio Tsuchida
IPC分类号: A01N43/02 , A61K31/335 , C07D313/00 , C07D313/04
CPC分类号: A61K31/336 , A61K31/366 , A61K31/4025 , A61K31/4427 , A61K31/4523 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/551 , C07D407/06
摘要: The present invention relates to a compound represented by the formula (I): (wherein, R3, R6, R7 and R21 are the same as or different from one another and each represents a hydroxyl group etc.), a pharmacologically acceptable salt thereof or a hydrate of them. The compound (I) of the present invention suppresses angiogenesis, in particular, suppresses VEGF production in a hypoxic condition and is useful as a therapeutic agent for treating solid cancer.
摘要翻译: 本发明涉及由式(I)表示的化合物:其中R3,R6,R7和R21彼此相同或不同,各自表示羟基等),其药理学上可接受的盐或 它们的水合物。 本发明的化合物(I)抑制血管生成,特别是在缺氧条件下抑制VEGF的产生,可用作治疗实体癌的治疗剂。
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公开(公告)号:US07893068B2
公开(公告)日:2011-02-22
申请号:US11927564
申请日:2007-10-29
申请人: Yoshihiko Kotake , Jun Niijima , Yoshio Fukuda , Mitsuo Nagai , Regina Mikie Kanada , Takashi Nakashima , Masahi Yoshida , Toshio Tsuchida
发明人: Yoshihiko Kotake , Jun Niijima , Yoshio Fukuda , Mitsuo Nagai , Regina Mikie Kanada , Takashi Nakashima , Masahi Yoshida , Toshio Tsuchida
IPC分类号: A61K31/496 , A61K31/365 , C07D313/00 , C07D405/12 , A61P19/02 , A61P29/00 , A61P35/00 , A61P9/10
CPC分类号: A61K31/336 , A61K31/366 , A61K31/4025 , A61K31/4427 , A61K31/4523 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/551 , C07D407/06
摘要: The present invention relates to a compound represented by the formula (I): (wherein, R3, R6, R7 and R21 are the same as or different from one another and each represents a hydroxyl group etc.), a pharmacologically acceptable salt thereof or a hydrate of them. The compound (I) of the present invention suppresses angiogenesis, in particular, suppresses VEGF production in a hypoxic condition and is useful as a therapeutic agent for treating solid cancer.
摘要翻译: 本发明涉及由式(I)表示的化合物:其中R3,R6,R7和R21彼此相同或不同,各自表示羟基等),其药理学上可接受的盐或 它们的水合物。 本发明的化合物(I)抑制血管生成,特别是在缺氧条件下抑制VEGF的产生,可用作治疗实体癌的治疗剂。
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公开(公告)号:US20080255146A1
公开(公告)日:2008-10-16
申请号:US11927564
申请日:2007-10-29
申请人: Yoshihiko KOTAKE , Jun Niijima , Yoshio Fukuda , Mitsuo Nagai , Regina Mikie Kanada , Takashi Nakashima , Masahi Yoshida , Toshio Tsuchida
发明人: Yoshihiko KOTAKE , Jun Niijima , Yoshio Fukuda , Mitsuo Nagai , Regina Mikie Kanada , Takashi Nakashima , Masahi Yoshida , Toshio Tsuchida
IPC分类号: A61K31/496 , C07D313/00 , A61K31/365 , A61P19/02 , A61P29/00 , A61P35/00 , A61P9/10 , C07D405/12
CPC分类号: A61K31/336 , A61K31/366 , A61K31/4025 , A61K31/4427 , A61K31/4523 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/551 , C07D407/06
摘要: The present invention relates to a compound represented by the formula (I): (wherein, R3, R6, R7 and R21 are the same as or different from one another and each represents a hydroxyl group etc.), a pharmacologically acceptable salt thereof or a hydrate of them. The compound (I) of the present invention suppresses angiogenesis, in particular, suppresses VEGF production in a hypoxic condition and is useful as a therapeutic agent for treating solid cancer.
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公开(公告)号:US07256178B2
公开(公告)日:2007-08-14
申请号:US10522731
申请日:2003-07-31
申请人: Yoshihiko Kotake , Jun Niijima , Yoshio Fukuda , Mitsuo Nagai , Regina Mikie Kanada , Susumu Takeda , Takashi Nakashima , Masashi Yoshida , Toshio Tsuchida , Tomohiro Sameshima
发明人: Yoshihiko Kotake , Jun Niijima , Yoshio Fukuda , Mitsuo Nagai , Regina Mikie Kanada , Susumu Takeda , Takashi Nakashima , Masashi Yoshida , Toshio Tsuchida , Tomohiro Sameshima
CPC分类号: C07D407/06 , C07D313/00 , C12P17/08 , C12P17/16 , C12P17/162
摘要: Compounds represented by the following general formula (I), pharmacologically acceptable salts thereof or hydrates of the same: (I) wherein W represents and R3, R7, R16, R17, R20, R21 and R21′ are the same or different and each represents hydrogen, etc. Because of inhibiting angiogenesis and inhibiting the production of VEGF particularly in hypoxia, the compounds (I) are useful as remedies for solid cancer.
摘要翻译: 由以下通式(I)表示的化合物,其药学上可接受的盐或其水合物:其中W表示和R 3,R 7,R 7, SUP> 16,R 17,R 20,R 21和R 21'是 相同或不同,各自表示氢等。由于抑制血管生成并抑制VEGF的产生,特别是在缺氧中,化合物(I)可用作固体癌症的补救措施。
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公开(公告)号:US20060009439A1
公开(公告)日:2006-01-12
申请号:US10515647
申请日:2003-05-29
申请人: Yoshihiko Kotake , Jun Niijima , Yoshio Fukuda , Mitsuo Nagai , Regina Kanada , Takashi Nakashima , Masahi Yoshida , Toshio Tsuchida
发明人: Yoshihiko Kotake , Jun Niijima , Yoshio Fukuda , Mitsuo Nagai , Regina Kanada , Takashi Nakashima , Masahi Yoshida , Toshio Tsuchida
IPC分类号: A61K31/33
CPC分类号: A61K31/336 , A61K31/366 , A61K31/4025 , A61K31/4427 , A61K31/4523 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/551 , C07D407/06
摘要: The present invention relates to a compound represented by the formula (I): (wherein, R3, R6, R7 and R21 are the same as or different from one another and each represents a hydroxyl group etc.), a pharmacologically acceptable salt thereof or a hydrate of them. The compound (I) of the present invention suppresses angiogenesis, in particular, suppresses VEGF production in a hypoxic condition and is useful as a therapeutic agent for treating solid cancer.
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公开(公告)号:US20060241171A1
公开(公告)日:2006-10-26
申请号:US11473201
申请日:2006-06-23
申请人: Yoshihiko Kotake , Jun Niijima , Yoshio Fukuda , Mitsuo Nagai , Regina Kanada , Takashi Nakashima , Masahi Yoshida , Toshio Tsuchida
发明人: Yoshihiko Kotake , Jun Niijima , Yoshio Fukuda , Mitsuo Nagai , Regina Kanada , Takashi Nakashima , Masahi Yoshida , Toshio Tsuchida
IPC分类号: A61K31/365 , C07D313/04 , C07D405/02
CPC分类号: A61K31/336 , A61K31/366 , A61K31/4025 , A61K31/4427 , A61K31/4523 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/551 , C07D407/06
摘要: The present invention relates to a compound represented by the formula (I): (wherein, R3, R6, R7 and R21 are the same as or different from one another and each represents a hydroxyl group etc.), a pharmacologically acceptable salt thereof or a hydrate of them. The compound (I) of the present invention suppresses angiogenesis, in particular, suppresses VEGF production in a hypoxic condition and is useful as a therapeutic agent for treating solid cancer.
摘要翻译: 本发明涉及由式(I)表示的化合物:其中R 3,R 6,R 7和R 7, SUP> 21个彼此相同或不同,各自表示羟基等),其药理学上可接受的盐或它们的水合物。 本发明的化合物(I)抑制血管生成,特别是在缺氧条件下抑制VEGF的产生,可用作治疗实体癌的治疗剂。
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公开(公告)号:US20050245514A1
公开(公告)日:2005-11-03
申请号:US10522731
申请日:2003-07-31
申请人: Yoshihiko Kotake , Jun Niijima , Yoshio Fukuda , Mitsuo Nagai , Regina Kanada , Susumu Takeda , Takashi Nakashima , Masashi Yoshida , Toshio Tsuchida , Tomohiro Sameshima
发明人: Yoshihiko Kotake , Jun Niijima , Yoshio Fukuda , Mitsuo Nagai , Regina Kanada , Susumu Takeda , Takashi Nakashima , Masashi Yoshida , Toshio Tsuchida , Tomohiro Sameshima
IPC分类号: C07D313/00 , A61P3/10 , A61P9/00 , A61P9/10 , A61P17/06 , A61P19/02 , A61P27/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07D407/06 , C12P17/08 , C12P17/16 , A61K31/5377 , A61K31/365 , A61K31/4025 , A61K31/452 , A61K31/496 , C07D413/02 , C07D45/02
CPC分类号: C07D407/06 , C07D313/00 , C12P17/08 , C12P17/16 , C12P17/162
摘要: Compounds represented by the following general formula (I), pharmacologically acceptable salts thereof or hydrates of the same: (I) wherein W represents and R3, R7, R16, R17, R20, R21 and R21′ are the same or different and each represents hydrogen, etc. Because of inhibiting angiogenesis and inhibiting the production of VEGF particularly in hypoxia, the compounds (I) are useful as remedies for solid cancer.
摘要翻译: 由以下通式(I)表示的化合物,其药学上可接受的盐或其水合物:其中W表示和R 3,R 7,R 7, SUP> 16,R 17,R 20,R 21和R 21'是 相同或不同,各自表示氢等。由于抑制血管生成并抑制VEGF的产生,特别是在缺氧中,所以化合物(I)可用作固体癌的治疗方法。
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公开(公告)号:US20060079572A1
公开(公告)日:2006-04-13
申请号:US11213962
申请日:2005-08-30
申请人: Yoshiharu Mizui , Takashi Sakai , Satoshi Yamamoto , Keisuke Komeda , Masanori Fujita , Akifumi Okuda , Kumiko Kishi , Jun Niijima , Mitsuo Nagai , Kiyoshi Okamoto , Masao Iwata , Yoshihiko Kotake , Toshimitsu Uenaka , Naoki Asai , Motoko Matsufuji , Tomohiro Sameshima , Naoto Kawamura , Kazuyuki Dobashi , Takashi Nakashima , Masashi Yoshida , Toshio Tsuchida , Susumu Takeda , Tomonari Yamada , Koji Norihisa , Takao Yamori
发明人: Yoshiharu Mizui , Takashi Sakai , Satoshi Yamamoto , Keisuke Komeda , Masanori Fujita , Akifumi Okuda , Kumiko Kishi , Jun Niijima , Mitsuo Nagai , Kiyoshi Okamoto , Masao Iwata , Yoshihiko Kotake , Toshimitsu Uenaka , Naoki Asai , Motoko Matsufuji , Tomohiro Sameshima , Naoto Kawamura , Kazuyuki Dobashi , Takashi Nakashima , Masashi Yoshida , Toshio Tsuchida , Susumu Takeda , Tomonari Yamada , Koji Norihisa , Takao Yamori
IPC分类号: A61K31/365 , C07D313/00
CPC分类号: C07D405/14 , A61K31/335 , A61K31/336 , A61K31/4025 , A61K31/4427 , A61K31/4523 , A61K31/455 , A61K31/496 , A61K31/5377 , A61K31/74 , C07D313/00 , C07D407/06 , C07D407/14 , C07D493/04 , C07D493/08 , C12P17/02
摘要: The present invention provides a novel bioactive substance having an antitumor activity and a process for producing it, and a medical use thereof. Namely, it provides a 12-membered ring macrolide compound represented by the following formula obtained from the incubation solution of Streptomyces sp. Mer. 11107 or a variant thereof, a pharmacologically acceptable salt thereof or a hydrate of them, and a process for producing it.
摘要翻译: 本发明提供了具有抗肿瘤活性的新型生物活性物质及其制造方法及其医疗用途。 即,它提供了由下列公式表示的12元环大环内酯化合物,其由Streptomyces sp。 梅尔 11107或其变体,其药理学上可接受的盐或它们的水合物及其制备方法。
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