发明申请
US20080261895A1 Isolated hydroxy and n-oxide metabolites and derivatives of O-desmethylvenlafaxine and methods of treatment
审中-公开
分离的羟基和N-氧化物代谢物及其衍生物的O-去甲基文拉法辛及其治疗方法
- 专利标题： Isolated hydroxy and n-oxide metabolites and derivatives of O-desmethylvenlafaxine and methods of treatment
- 专利标题（中）： 分离的羟基和N-氧化物代谢物及其衍生物的O-去甲基文拉法辛及其治疗方法
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申请号： US11976413申请日： 2007-10-24
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公开(公告)号： US20080261895A1公开(公告)日： 2008-10-23
- 发明人: Matthew J. Hoffmann , William DeMaio , Jim Wang , John W. Ullrich
- 申请人： Matthew J. Hoffmann , William DeMaio , Jim Wang , John W. Ullrich
- 专利权人： Wyeth
- 当前专利权人： Wyeth
- 主分类号： A61K31/7032
- IPC分类号： A61K31/7032 ; A61K31/138 ; C07C215/46 ; A61K31/14 ; C07C211/63 ; C07H15/20
摘要：
The present invention provides novel isolated compounds characterized as metabolites or derivatives of desmethylvenlafaxine including hydroxy-DV metabolites, hydroxy-DV-glucuronide metabolites, N-oxide-DV metabolites, and benzyl-hydroxy-DV metabolites. The invention includes pharmaceutical compositions comprising any of the metabolites or derivatives of the invention in combination with a pharmaceutically acceptable carrier or excipient. The invention also includes a method of treating at least one central nervous system disorder in a mammal comprising providing to a mammal in need thereof an effective amount of the compounds of the invention.