发明申请
- 专利标题: Use of Apoptotic Cells Ex Vivo to Generate Regulatory T Cells
- 专利标题(中): 使用凋亡细胞体外产生调节性T细胞
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申请号: US11579319申请日: 2006-11-02
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公开(公告)号: US20080267934A1公开(公告)日: 2008-10-30
- 发明人: David Peritt , Kim Campbell , Amy Krutsick
- 申请人: David Peritt , Kim Campbell , Amy Krutsick
- 国际申请: PCT/US06/42581 WO 20061102
- 主分类号: A61K35/14
- IPC分类号: A61K35/14 ; C12N5/02 ; A61P1/00 ; A61P25/28
摘要:
Many cell types in the body can remove apoptotic and cellular debris from tissues; however, the professional phagocyte, or antigen presenting cell (“APC”), has a high capacity to do so. The recognition of apoptotic cells (“ACs”) occurs via a series of evolutionarily-conserved, AC associated molecular-pattern receptors (“ACAMPRs”) on APCs that recognize and bind corresponding apoptotic-cell-associated molecular patterns (“ACAMPs”). These receptors recognize ligands such as phosphotidyl serine and oxidized lipids found on apoptotic cells. Savill et al. (2002); and Gregory et al. (2004).
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