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    Use of apoptotic cells ex vivo to generate regulatory T cells
    1.
    发明授权
    Use of apoptotic cells ex vivo to generate regulatory T cells 有权
    使用凋亡细胞离体产生调节性T细胞

    公开(公告)号：US09169461B2

    公开(公告)日：2015-10-27

    申请号：US11579319

    申请日：2006-11-02

    Applicant: David Peritt ,  Kim Campbell ,  Amy Krutsick

    Inventor： David Peritt ,  Kim Campbell ,  Amy Krutsick

    IPC: C12N5/0783 ,  A61K31/366 ,  A61K31/59 ,  A61K35/17

    CPC classification number: C12N5/0637 ,  A61K31/366 ,  A61K31/59 ,  A61K35/17 ,  C12N5/0636 ,  C12N2500/38 ,  C12N2501/15 ,  C12N2501/23 ,  C12N2501/231 ,  C12N2501/39 ,  C12N2502/11

    Abstract: Many cell types in the body can remove apoptotic and cellular debris from tissues; however, the professional phagocyte, or antigen presenting cell (“APC”), has a high capacity to do so. The recognition of apoptotic cells (“ACs”) occurs via a series of evolutionarily-conserved, AC associated molecular-pattern receptors (“ACAMPRs”) on APCs that recognize and bind corresponding apoptotic-cell-associated molecular patterns (“ACAMPs”). These receptors recognize ligands such as phosphotidyl serine and oxidized lipids found on apoptotic cells. Savill et al. (2002); and Gregory et al. (2004).

    Abstract translation: 身体中的许多细胞类型可以从组织中去除凋亡和细胞碎片; 然而，专业吞噬细胞或抗原呈递细胞（“APC”）具有很高的能力。 凋亡细胞（“AC”）的识别通过一系列进化保守的AC相关分子模式受体（“ACAMPR”）在APC上发生，其识别并结合相应的凋亡细胞相关分子模式（“ACAMP”）。 这些受体识别在凋亡细胞上发现的配体如磷脂酰丝氨酸和氧化的脂质。 Savill等人 （2002）; 和格雷戈里（Gregory）等 （2004）。

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