发明申请
US20080269257A1 Use of Substituted 2-Pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-A] Pyrimidin-4-one and 7-Pyrimidinyl-2,3-dihydroimidazo[1,2-A] Pyrimidin-5(1H)one Derivatives
失效
使用取代的2-嘧啶基-6,7,8,9-四氢嘧啶并[1,2-A]嘧啶-4-酮和7-嘧啶基-2,3-二氢咪唑并[1,2-A]嘧啶-5（1H ）一个衍生品
![Use of Substituted 2-Pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-A] Pyrimidin-4-one and 7-Pyrimidinyl-2,3-dihydroimidazo[1,2-A] Pyrimidin-5(1H)one Derivatives](/docs/US/2008-10-30/US20080269257A1/abs.jpg.600x600.jpg)
- 专利标题： Use of Substituted 2-Pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-A] Pyrimidin-4-one and 7-Pyrimidinyl-2,3-dihydroimidazo[1,2-A] Pyrimidin-5(1H)one Derivatives
- 专利标题（中）： 使用取代的2-嘧啶基-6,7,8,9-四氢嘧啶并[1,2-A]嘧啶-4-酮和7-嘧啶基-2,3-二氢咪唑并[1,2-A]嘧啶-5（1H ）一个衍生品
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申请号： US12120496申请日： 2008-05-14
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公开(公告)号： US20080269257A1公开(公告)日： 2008-10-30
- 发明人: Thierry Gallet , Patrick Lardenois , Alistair Lochead , Severine Marguerie , Alain Nedelec , Mourad Saady , Franck Slowinski , Philippe Yaiche
- 申请人： Thierry Gallet , Patrick Lardenois , Alistair Lochead , Severine Marguerie , Alain Nedelec , Mourad Saady , Franck Slowinski , Philippe Yaiche
- 申请人地址： FR Paris JP Osaka
- 专利权人： SANOFI-AVENTIS,MITSUBISHI PHARMA CORPORATION
- 当前专利权人： SANOFI-AVENTIS,MITSUBISHI PHARMA CORPORATION
- 当前专利权人地址： FR Paris JP Osaka
- 优先权： EP01402431.9 20010921; EP02290488.2 20020228
- 主分类号： A61K31/519
- IPC分类号： A61K31/519 ; C07D487/02 ; A61P25/28 ; A61P25/00
![Use of Substituted 2-Pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-A] Pyrimidin-4-one and 7-Pyrimidinyl-2,3-dihydroimidazo[1,2-A] Pyrimidin-5(1H)one Derivatives](/abs-image/US/2008/10/30/US20080269257A1/abs.jpg.150x150.jpg)
摘要：
The invention relates to use of a pyrimidone derivative represented by formula (I) or a salt thereof as therapeutic agents: Wherein m, n, p, X, Y, R1, R2, R3, R4 R5, are as defined herein. The invention specifically relates to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3β or GSK3β and cdk5/p25, such as Alzheimer disease.
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