发明申请
- 专利标题： Dual-acting antihypertensive agents
- 专利标题（中）： 双作用抗高血压药
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申请号： US12148872申请日： 2008-04-23
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公开(公告)号： US20080269305A1公开(公告)日： 2008-10-30
- 发明人: Paul Allegretti , Seok-Ki Choi , Roland Gendron , Paul R. Fatheree , Keith Jendza , Robert Murray McKinnell , Darren McMurtrie , Brooke Olson
- 申请人： Paul Allegretti , Seok-Ki Choi , Roland Gendron , Paul R. Fatheree , Keith Jendza , Robert Murray McKinnell , Darren McMurtrie , Brooke Olson
- 专利权人： Theravance, Inc.
- 当前专利权人： Theravance, Inc.
- 主分类号： A61K31/41
- IPC分类号： A61K31/41 ; C07D233/68 ; A61K31/4174 ; G01N33/53 ; A61P9/04 ; A61P9/12 ; G01N33/566 ; C07K14/705 ; C07D403/08
摘要：
The invention is directed to compounds having the formula: wherein: Ar, r, Y, Z, Q, W, X, and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
公开/授权文献
- US08013005B2 Dual-acting antihypertensive agents 公开/授权日：2011-09-06
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