发明申请
- 专利标题： Endosomolytic Poly-Beta-Aminoester Polymers
- 专利标题（中）： 内聚糖多聚β-氨基酯聚合物
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申请号： US12140741申请日： 2008-06-17
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公开(公告)号： US20080269450A1公开(公告)日： 2008-10-30
- 发明人: Darren H. Wakefield , David B. Rozema , Sean D. Monahan , Andrei Blokhin , Lori Higgs , Jon A. Wolff , James E. Hagstrom
- 申请人： Darren H. Wakefield , David B. Rozema , Sean D. Monahan , Andrei Blokhin , Lori Higgs , Jon A. Wolff , James E. Hagstrom
- 主分类号： C08G69/02
- IPC分类号： C08G69/02 ; C08F251/00
摘要：
The present invention is directed to membrane active polymers useful for cellular delivery of compounds. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery conjugates. The use of reversible modification provides for physiologically responsive activity modulation.