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公开(公告)号：US20080269450A1
公开(公告)日：2008-10-30
申请号：US12140741
申请日：2008-06-17
申请人： Darren H. Wakefield , David B. Rozema , Sean D. Monahan , Andrei Blokhin , Lori Higgs , Jon A. Wolff , James E. Hagstrom
发明人： Darren H. Wakefield , David B. Rozema , Sean D. Monahan , Andrei Blokhin , Lori Higgs , Jon A. Wolff , James E. Hagstrom
IPC分类号： C08G69/02 , C08F251/00
CPC分类号： C12N15/87 , A01K2217/058 , A01K2267/0362 , A61K47/58 , A61K48/0041
摘要： The present invention is directed to membrane active polymers useful for cellular delivery of compounds. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery conjugates. The use of reversible modification provides for physiologically responsive activity modulation.
摘要翻译： 本发明涉及可用于细胞递送化合物的膜活性聚合物。 描述了将靶向，抗调理作用，抗聚集和转染活性结合到小的生物相容性体内递送缀合物中的多偶联体系。 使用可逆修饰提供了生理反应活性调节。
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公开(公告)号：US08017109B2
公开(公告)日：2011-09-13
申请号：US12140703
申请日：2008-06-17
申请人： Darren H. Wakefield , David B. Rozema , Sean D. Monahan , Lori Higgs , Jon A. Wolff , James E. Hagstrom
发明人： Darren H. Wakefield , David B. Rozema , Sean D. Monahan , Lori Higgs , Jon A. Wolff , James E. Hagstrom
IPC分类号： A61K31/74
CPC分类号： C12N15/87 , A01K2217/058 , A01K2267/0362 , A61K47/58
摘要： The present invention is directed to membrane active polymers useful for cellular delivery of compounds. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery conjugates. The use of reversible modification provides for physiologically responsive activity modulation.
摘要翻译： 本发明涉及可用于细胞递送化合物的膜活性聚合物。 描述了将靶向，抗调理作用，抗聚集和转染活性结合到小的生物相容性体内递送缀合物中的多偶联体系。 使用可逆修饰提供了生理反应活性调节。
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公开(公告)号：US20080287630A1
公开(公告)日：2008-11-20
申请号：US12140703
申请日：2008-06-17
申请人： Darren H. Wakefield , David B. Rozema , Sean D. Monahan , Lori Higgs , Jon A. Wolff , James E. Hagstrom
发明人： Darren H. Wakefield , David B. Rozema , Sean D. Monahan , Lori Higgs , Jon A. Wolff , James E. Hagstrom
IPC分类号： C08F220/52
CPC分类号： C12N15/87 , A01K2217/058 , A01K2267/0362 , A61K47/58
摘要： The present invention is directed to membrane active polymers useful for cellular delivery of compounds. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery conjugates. The use of reversible modification provides for physiologically responsive activity modulation.
摘要翻译： 本发明涉及可用于细胞递送化合物的膜活性聚合物。 描述了将靶向，抗调理作用，抗聚集和转染活性结合到小的生物相容性体内递送缀合物中的多偶联体系。 使用可逆修饰提供了生理反应活性调节。
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公开(公告)号：US08008355B2
公开(公告)日：2011-08-30
申请号：US12140681
申请日：2008-06-17
申请人： David B. Rozema , Darren H. Wakefield , Sean D. Monahan , Lori Higgs , Jon A. Wolff , James E. Hagstrom
发明人： David B. Rozema , Darren H. Wakefield , Sean D. Monahan , Lori Higgs , Jon A. Wolff , James E. Hagstrom
CPC分类号： C12N15/87 , A01K2217/058 , A01K2267/0362 , A61K47/58
摘要： The present invention is directed to membrane active polymers useful for cellular delivery of compounds. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery conjugates. The use of reversible modification provides for physiologically responsive activity modulation.
摘要翻译： 本发明涉及可用于细胞递送化合物的膜活性聚合物。 描述了将靶向，抗调理作用，抗聚集和转染活性结合到小的生物相容性体内递送缀合物中的多偶联体系。 使用可逆修饰提供了生理反应活性调节。
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公开(公告)号：US20090023890A1
公开(公告)日：2009-01-22
申请号：US12123124
申请日：2008-05-19
申请人： Sean D. Monahan , Darren H. Wakefield , David B. Rozema , Lori Higgs , Jon A. Wolff , James E. Hagstrom
发明人： Sean D. Monahan , Darren H. Wakefield , David B. Rozema , Lori Higgs , Jon A. Wolff , James E. Hagstrom
IPC分类号： C08G73/02
CPC分类号： C12N15/87 , A01K2217/058 , A01K2267/0362 , A61K47/58 , A61K48/0041
摘要： The present invention is directed to a class of membrane active polymers useful for cellular delivery of compounds. Conjugation of the described membrane active polymers to targeting, anti-opsonization, and anti-aggregation agents provides polymers suitable for in vivo delivery. The use of multiple reversible linkages connecting component parts provides for physiologically responsive activity modulation.
摘要翻译： 本发明涉及一类可用于细胞递送化合物的膜活性聚合物。 所述膜活性聚合物与靶向，抗调理作用和抗聚集剂的结合提供了适合于体内递送的聚合物。 连接组成部分的多个可逆连接的使用提供了生理响应活性调节。
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公开(公告)号：US07985406B2
公开(公告)日：2011-07-26
申请号：US12123124
申请日：2008-05-19
申请人： Sean D. Monahan , Darren H. Wakefield , David B. Rozema , Lori Higgs , Jon A. Wolff , James E. Hagstrom
发明人： Sean D. Monahan , Darren H. Wakefield , David B. Rozema , Lori Higgs , Jon A. Wolff , James E. Hagstrom
IPC分类号： A61K31/74
CPC分类号： C12N15/87 , A01K2217/058 , A01K2267/0362 , A61K47/58 , A61K48/0041
摘要： The present invention is directed to a class of membrane active polymers useful for cellular delivery of compounds. Conjugation of the described membrane active polymers to targeting, anti-opsonization, and anti-aggregation agents provides polymers suitable for in vivo delivery. The use of multiple reversible linkages connecting component parts provides for physiologically responsive activity modulation.
摘要翻译： 本发明涉及一类可用于细胞递送化合物的膜活性聚合物。 所述膜活性聚合物与靶向，抗调理作用和抗聚集剂的结合提供了适合于体内递送的聚合物。 连接组成部分的多个可逆连接的使用提供了生理响应活性调节。
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公开(公告)号：US20080287628A1
公开(公告)日：2008-11-20
申请号：US12140681
申请日：2008-06-17
申请人： David B. Rozema , Darren H. Wakefield , Sean D. Monahan , Lori Higgs , Jon A. Wolff , James E. Hagstrom
发明人： David B. Rozema , Darren H. Wakefield , Sean D. Monahan , Lori Higgs , Jon A. Wolff , James E. Hagstrom
IPC分类号： C08F26/06
CPC分类号： C12N15/87 , A01K2217/058 , A01K2267/0362 , A61K47/58
摘要： The present invention is directed to membrane active polymers useful for cellular delivery of compounds. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery conjugates. The use of reversible modification provides for physiologically responsive activity modulation.
摘要翻译： 本发明涉及可用于细胞递送化合物的膜活性聚合物。 描述了将靶向，抗调理作用，抗聚集和转染活性结合到小的生物相容性体内递送缀合物中的多偶联体系。 使用可逆修饰提供了生理反应活性调节。
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公开(公告)号：US20080281044A1
公开(公告)日：2008-11-13
申请号：US12140736
申请日：2008-06-17
申请人： Sean D. Monahan , Lori Higgs , Darren H. Wakefield , David B. Rozema , Jon A. Wolff , James E. Hagstrom
发明人： Sean D. Monahan , Lori Higgs , Darren H. Wakefield , David B. Rozema , Jon A. Wolff , James E. Hagstrom
IPC分类号： C08F216/06 , C08G73/00
CPC分类号： C12N15/87 , A01K2217/058 , A01K2267/0362 , A61K47/58 , A61K48/0041
摘要： The present invention is directed to membrane active polymers useful for cellular delivery of compounds. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery conjugates. The use of reversible modification provides for physiologically responsive activity modulation.
摘要翻译： 本发明涉及可用于细胞递送化合物的膜活性聚合物。 描述了将靶向，抗调理作用，抗聚集和转染活性结合到小的生物相容性体内递送缀合物中的多偶联体系。 使用可逆修饰提供了生理反应活性调节。
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公开(公告)号：US07501394B2
公开(公告)日：2009-03-10
申请号：US11337121
申请日：2006-01-20
申请人： Alexander V. Sokoloff , So Wong , Jon A. Wolff , Sean D. Monahan , James Ludtke , Lori Higgs , Darren H. Wakefield , Magdolna G. Sebestyén
发明人： Alexander V. Sokoloff , So Wong , Jon A. Wolff , Sean D. Monahan , James Ludtke , Lori Higgs , Darren H. Wakefield , Magdolna G. Sebestyén
IPC分类号： A61K38/00
CPC分类号： C07K14/005 , A61K41/00 , C12N2795/10222
摘要： We describe compounds that bind to and are internalized by hepatocytes. Association of these compounds to other molecules or complexes can be used to target the molecules or complexes to hepatocytes in vivo or in vitro.
摘要翻译： 我们描述与肝细胞结合并被内化的化合物。 这些化合物与其他分子或复合物的结合可用于在体内或体外靶向肝细胞的分子或复合物。
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10.发明授权Compositions and processes using siRNA, amphipathic compounds and polycations 有权使用siRNA，两亲性化合物和聚阳离子的组合物和方法公开(公告)号：US07601367B2
公开(公告)日：2009-10-13
申请号：US10845968
申请日：2004-05-14
申请人： Sean D. Monahan , David L. Lewis , Hans Herweijer , Jon A. Wolff , James E. Hagstrom , Aaron G. Loomis , Vladimir Trubetskoy , Lori Higgs
发明人： Sean D. Monahan , David L. Lewis , Hans Herweijer , Jon A. Wolff , James E. Hagstrom , Aaron G. Loomis , Vladimir Trubetskoy , Lori Higgs
CPC分类号： C12N15/111 , A61K31/495 , A61K31/58 , A61K31/7105 , A61K31/74 , A61K48/0025 , A61K48/0041 , C07H21/04 , C12N15/88 , C12N2310/14 , C12N2320/32 , A61K2300/00
摘要： Described is a deliverable composition with low toxicity comprising an amphipathic compound, a polycation, and a siRNA. The composition may be used in the process of delivering a siRNA to an animal cell or more particularly, a mammal cell.
摘要翻译： 描述了具有低毒性的可递送组合物，其包含两亲性化合物，聚阳离子和siRNA。 组合物可以用于将siRNA递送到动物细胞或更特别是哺乳动物细胞的过程中。
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