发明申请
- 专利标题: Precursor Compound of Radioactive Halogen-Labeled Organic Compound
- 专利标题(中): 放射性标记有机化合物的前体化合物
-
申请号: US12085679申请日: 2006-11-28
-
公开(公告)号: US20080281121A1公开(公告)日: 2008-11-13
- 发明人: Osamu Ito , Akio Hayashi , Fumie Kurosaki , Masahito Toyama , Toshiyuki Shinmura , Arinori Harano
- 申请人: Osamu Ito , Akio Hayashi , Fumie Kurosaki , Masahito Toyama , Toshiyuki Shinmura , Arinori Harano
- 申请人地址: JP Tokyo
- 专利权人: NIHON MEDI-PHYSICS CO., LTD.
- 当前专利权人: NIHON MEDI-PHYSICS CO., LTD.
- 当前专利权人地址: JP Tokyo
- 优先权: JP2005-343653 20051129
- 国际申请: PCT/JP2006/323659 WO 20061128
- 主分类号: C07C69/74
- IPC分类号: C07C69/74
摘要:
It is intended to provide a novel amino acid organic compound which can be used as a labeling precursor compound for radioactive halogen-labeled amino acid compounds including [18F]FACBC, and which prevents methanol from remaining in the radioactive halogen-labeled amino acid compounds produced therefrom. The novel amino acid organic compound is a compound represented by the following formula: wherein n is an integer of 0 or of 1 to 4; R1 is an ethyl, 1-propyl or isopropyl substituent; X is a halogen substituent or a group represented by —OR2; R2 is a straight-chain or branched-chain haloalkylsulfonic acid substituent with one to 10 carbon atoms, trialkylstannyl substituent with 3 to 12 carbon atoms, fluorosulfonic acid substituent or aromatic sulfonic acid substituent; and R3 is a protective group.
公开/授权文献
- US08758724B2 Unnatural amino acid radiolabeling precursor 公开/授权日:2014-06-24
信息查询