公开(公告)号：US20080281121A1

公开(公告)日：2008-11-13

申请号：US12085679

申请日：2006-11-28

申请人： Osamu Ito ,  Akio Hayashi ,  Fumie Kurosaki ,  Masahito Toyama ,  Toshiyuki Shinmura ,  Arinori Harano

发明人： Osamu Ito ,  Akio Hayashi ,  Fumie Kurosaki ,  Masahito Toyama ,  Toshiyuki Shinmura ,  Arinori Harano

IPC分类号： C07C69/74

CPC分类号： A61K51/0402 ,  A61K51/0406 ,  C07B59/00 ,  C07B2200/05 ,  C07C67/307 ,  C07C309/65 ,  C07C2601/04 ,  Y02P20/55

摘要： It is intended to provide a novel amino acid organic compound which can be used as a labeling precursor compound for radioactive halogen-labeled amino acid compounds including [18F]FACBC, and which prevents methanol from remaining in the radioactive halogen-labeled amino acid compounds produced therefrom. The novel amino acid organic compound is a compound represented by the following formula: wherein n is an integer of 0 or of 1 to 4; R1 is an ethyl, 1-propyl or isopropyl substituent; X is a halogen substituent or a group represented by —OR2; R2 is a straight-chain or branched-chain haloalkylsulfonic acid substituent with one to 10 carbon atoms, trialkylstannyl substituent with 3 to 12 carbon atoms, fluorosulfonic acid substituent or aromatic sulfonic acid substituent; and R3 is a protective group.

摘要翻译： 旨在提供一种新的氨基酸有机化合物，其可用作用于放射性卤素标记的氨基酸化合物的标记前体化合物，包括[SUP 18 F] FACBC，并且其防止甲醇残留在 由其制备的放射性卤素标记的氨基酸化合物。 新型氨基酸有机化合物是下式表示的化合物：其中，n为0或1〜4的整数， R 1是乙基，1-丙基或异丙​​基取代基; X是卤素取代基或由-OR 2表示的基团。 R 2是具有1至10个碳原子的直链或支链卤代烷基磺酸取代基，具有3至12个碳原子的三烷基甲锡烷基取代基，氟代磺酸取代基或芳族磺酸取代基; R 3是保护基。

公开(公告)号：US08758724B2

公开(公告)日：2014-06-24

申请号：US12085679

申请日：2006-11-28

申请人： Osamu Ito ,  Akio Hayashi ,  Fumie Kurosaki ,  Masahito Toyama ,  Toshiyuki Shinmura ,  Arinori Harano

发明人： Osamu Ito ,  Akio Hayashi ,  Fumie Kurosaki ,  Masahito Toyama ,  Toshiyuki Shinmura ,  Arinori Harano

IPC分类号： A61K51/00 ,  A61M36/14

CPC分类号： A61K51/0402 ,  A61K51/0406 ,  C07B59/00 ,  C07B2200/05 ,  C07C67/307 ,  C07C309/65 ,  C07C2601/04 ,  Y02P20/55

摘要： It is intended to provide a novel amino acid organic compound which can be used as a labeling precursor compound for radioactive halogen-labeled amino acid compounds including [18F]FACBC, and which prevents methanol from remaining in the radioactive halogen-labeled amino acid compounds produced therefrom. The novel amino acid organic compound is a compound represented by the following formula: wherein n is an integer of 0 or of 1 to 4; R1 is an ethyl, 1-propyl or isopropyl substituent; X is a halogen substituent or a group represented by —OR2; R2 is a straight-chain or branched-chain haloalkylsulfonic acid substituent with one to 10 carbon atoms, trialkylstannyl substituent with 3 to 12 carbon atoms, fluorosulfonic acid substituent or aromatic sulfonic acid substituent; and R3 is a protective group.

摘要翻译： 旨在提供一种新的氨基酸有机化合物，其可以用作包括[18 F] FACBC的放射性卤素标记的氨基酸化合物的标记前体化合物，并且其防止甲醇残留在所产生的放射性卤素标记的氨基酸化合物中 由此。 新型氨基酸有机化合物是下式表示的化合物：其中，n为0或1〜4的整数， R1是乙基，1-丙基或异丙​​基取代基; X是卤素取代基或由-OR2表示的基团; R2是具有1至10个碳原子的直链或支链卤代烷基磺酸取代基，具有3至12个碳原子的三烷基甲锡烷基取代基，氟磺酸取代基或芳族磺酸取代基; R3为保护基。