发明申请
US20080287409A1 PHENYL AND PYRIDINYL-1,2,4-OXADIAZOLONE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS
审中-公开
苯乙基和吡啶基-1,2,4-氧杂二唑衍生物，其制备方法及其作为药物组合物的用途
- 专利标题： PHENYL AND PYRIDINYL-1,2,4-OXADIAZOLONE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS
- 专利标题（中）： 苯乙基和吡啶基-1,2,4-氧杂二唑衍生物，其制备方法及其作为药物组合物的用途
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申请号： US12055793申请日： 2008-03-26
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公开(公告)号： US20080287409A1公开(公告)日： 2008-11-20
- 发明人: Patrick Bernardelli , Stefanie Keil , Matthias Urmann , Hans Matter , Wolfgang Wendler , Maike Glien , Karen Chandross , Lan Lee , Corinne Terrier , Herve Minoux
- 申请人： Patrick Bernardelli , Stefanie Keil , Matthias Urmann , Hans Matter , Wolfgang Wendler , Maike Glien , Karen Chandross , Lan Lee , Corinne Terrier , Herve Minoux
- 申请人地址： FR Paris
- 专利权人： SANOFI-AVENTIS
- 当前专利权人： SANOFI-AVENTIS
- 当前专利权人地址： FR Paris
- 优先权： EP05021235.6 20050929
- 主分类号： A61K31/427
- IPC分类号： A61K31/427 ; A61K31/454 ; C07D413/14 ; C07D417/14 ; A61P3/10 ; A61P3/00 ; A61K31/5377 ; C07D417/12
摘要：
The present invention comprises phenyl and pyridinyl 1,2,4-oxadiazolone compounds their physiologically acceptable salts and physiologically functional derivatives that exhibit peroxisome proliferator activator receptor (PPAR) delta agonist activity. Also described and claimed are processes for their preparation and their use as pharmaceuticals. These are compounds of formula I, in which the R-group substituents are defined herein. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistance is involved and de-myelinating and other neurodegenerative disorders of the central and peripheral nervous system.
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