发明申请
- 专利标题： Phosphoramidate Derivatives of Fau
- 专利标题（中）： Fau的氨基磷酸衍生物
-
申请号： US12092999申请日： 2006-11-09
-
公开(公告)号： US20080292553A1公开(公告)日： 2008-11-27
- 发明人: Anthony F. Shields , Jiri Zemlicka , Sridhar Nimmagadda
- 申请人： Anthony F. Shields , Jiri Zemlicka , Sridhar Nimmagadda
- 国际申请： PCT/US06/43882 WO 20061109
- 主分类号： A61K31/7072
- IPC分类号： A61K31/7072 ; A61P35/00 ; C07H19/10 ; A61K49/00
摘要：
The present invention provides phosphoramidate derivatives of a furanosyluracil analog, FAU, that can effectively deliver FAU monophosphate, or a derivative thereof, intracellularly. FAU-Phosphoramidate diesters can bypass the first step of phosphorylation and be activated intracellularly so as to be converted to nucleoside monophosphates. This results in improved formation of nucleoside triphosphates, and higher incorporation into DNA. The compounds of the invention can be used to treat cancer.
公开/授权文献
- US07888330B2 Phosphoramidate derivatives of FAU 公开/授权日：2011-02-15
信息查询
IPC分类:
