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公开(公告)号：US20250066828A1
公开(公告)日：2025-02-27
申请号：US18724381
申请日：2023-01-10
Applicant: UAB BIOMATTER DESIGNS , ENGINZYME AB
Inventor： Martyna KOPLUNAITE , Nina URBELIENE , Rolandas MEŠKYS , Diana IKASALAITE , Linas ZAKRYS , Laurynas KARPUS , Federica RUGGIERI , Sascha GROBE
Abstract: Provided herein is a one-pot method of synthesising a C-nucleoside-5′-monophosphate such as pseudouridine-5′-monophosphate, from an N-nucleoside using a multi-step enzymatic pathway. The method comprises reacting the N-nucleoside with a phosphate source and nucleoside phosphorylase to form a pentose-1-phosphate intermediate, reacting the pentose-1-phosphate intermediate with a phosphomutase to form pentose-5-phosphate intermediate, and reacting the pentose-5-phosphate intermediate with a nucleoside-5′-phosphate C-glycosidase to form the C-nucleoside-5′-monophosphate.
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公开(公告)号：US20250064844A1
公开(公告)日：2025-02-27
申请号：US18940253
申请日：2024-11-07
Applicant: Emory University
Inventor： George R. PAINTER , Gregory R. BLUEMLING , Michael G. NATCHUS , Shuli MAO , Jose MARENGO , Michael W. HAGER , David PERRYMAN
IPC: A61K31/7068 , A61K9/00 , A61K31/34 , A61K31/341 , A61K31/403 , A61K31/404 , A61K31/4178 , A61K31/4406 , A61K31/496 , A61K31/4965 , A61K31/513 , A61K31/52 , A61K31/522 , A61K31/536 , A61K31/665 , A61K31/675 , A61K31/7076 , A61K45/06 , A61M11/00 , A61P31/14 , C07H19/06 , C07H19/10
Abstract: This disclosure relates to certain N4-hydroxycytidine derivatives, pharmaceutical compositions, and methods related thereto. In certain embodiments, the disclosure relates to the treatment or prophylaxis of human coronavirus 2019-nCoV.
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公开(公告)号：US12215122B2
公开(公告)日：2025-02-04
申请号：US18522886
申请日：2023-11-29
Applicant: Singular Genomics Systems, Inc.
Inventor： Ronald Graham , Olga Adelfinskaya , Megha Cila , Rodrigo Rodriguez , Abrehet Abdu , Eli N. Glezer
IPC: C12Q1/68 , C07H19/10 , C07H19/14 , C07H19/20 , C12Q1/6869 , C12Q1/6876
Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.
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公开(公告)号：US12187758B2
公开(公告)日：2025-01-07
申请号：US18359297
申请日：2023-07-26
Applicant: ROME Therapeutics, Inc.
Inventor： Donna L. Romero , Oliver Saunders , Gregory Stuart Bisacchi , Dennis Zaller , Rosana Kapeller-Libermann
IPC: C07H19/06 , A61P37/06 , C07H19/067 , C07H19/073 , C07H19/10 , C07H19/12 , C07H19/16
Abstract: The invention provides compounds, compositions and methods for treating medical disorders, such as cancer, an autoimmune disorder, and/or a neurological disorder, and inhibiting LINE1 reverse transcriptase and/or HERV-K reverse transcriptase using a compound according to Formula I or a pharmaceutically acceptable salt thereof, or a related compound provided herein.
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公开(公告)号：US20240360172A1
公开(公告)日：2024-10-31
申请号：US18756504
申请日：2024-06-27
Applicant: Lakewood Amedex, Inc.
Inventor： Randolph B. Sleet , Steven A. Kates , Steven Parkinson
Abstract: A method of treating an infection of a lung in a patient in need thereof according to an embodiment includes administering to the patient an effective amount of a compound having the formula:
or a pharmaceutically acceptable salt thereof.-
Patent Agency Ranking
公开(公告)号：US12121529B2
公开(公告)日：2024-10-22
申请号：US18511973
申请日：2023-11-16
Applicant: Gilead Sciences, Inc.
Inventor： Jinfa Du , Dhanapalan Nagarathnam , Michael Joseph Sofia , Peiyuan Wang
IPC: A61K31/7072 , A61K31/706 , A61K31/7064 , A61K31/7076 , A61K45/06 , C07D417/14 , C07H17/02 , C07H19/04 , C07H19/06 , C07H19/10 , C07H19/20 , A61K31/7068 , C07H19/073
CPC classification number: A61K31/7072 , A61K31/706 , A61K31/7064 , A61K31/7076 , A61K45/06 , C07D417/14 , C07H17/02 , C07H19/04 , C07H19/06 , C07H19/10 , C07H19/20 , A61K31/7068 , C07H19/073 , Y02A50/30
Abstract: Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt), hydrate, solvate, or crystalline form thereof, represented by the following structure:
Also disclosed are methods of treatment, uses, and processes for preparing each of which utilize the compound represented by formula I.-
公开(公告)号：US20240300992A1
公开(公告)日：2024-09-12
申请号：US18490328
申请日：2023-10-19
Applicant: Geron Corporation
Inventor： Sergei M. Gryaznov , Krisztina Pongracz , Daria Zielinska
Abstract: Orthogonally protected 3′-amino nucleoside monomers and efficient methods for their synthesis are described. The methods employ selective protection of the 3′-amino group in the presence of the unprotected nucleoside base.
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公开(公告)号：US12054511B2
公开(公告)日：2024-08-06
申请号：US17888312
申请日：2022-08-15
Applicant: NuCana plc
Inventor： Hugh Griffith , Gordon Kennovin , Venkata Lakshmi Narasimha Rao Dammalapati , Mani Bushan Kotala
IPC: C07H19/207 , C07H1/02 , C07H19/10 , C07H19/20
CPC classification number: C07H19/207 , C07H1/02 , C07H19/10 , C07H19/20
Abstract: The present invention is a process for the preparation of certain 5′-phosphoramidate nucleotide diastereoisomers. The phosphoramidates include those useful in the treatment of cancer such as NUC-3373 (5-fluoro-2′-deoxyuridine-5′-O-[1-naphthyl(benzyloxy-L-alaninyl)]phosphate].
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公开(公告)号：US20240226130A1
公开(公告)日：2024-07-11
申请号：US18479576
申请日：2023-10-02
Applicant: Gilead Sciences, Inc.
Inventor： Michael O. Clarke , Bindu Goyal , Richard L. Mackman , Devan Naduthambi , Neil H. Squires
IPC: A61K31/7076 , A61K31/7068 , A61K31/708 , A61K45/06 , A61P31/18 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/207
CPC classification number: A61K31/7076 , A61K31/7068 , A61K31/708 , A61K45/06 , A61P31/18 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/207
Abstract: Compounds, compositions, and methods useful for treating a viral infection, such as human immunodeficiency virus (HIV) infection, are disclosed. In particular, 4′-thionucleoside analogues and methods for their preparation and use as therapeutic or prophylactic agents are disclosed.
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公开(公告)号：US12030908B2
公开(公告)日：2024-07-09
申请号：US17856537
申请日：2022-07-01
Applicant: Lakewood Amedex, Inc.
Inventor： Randolph B. Sleet , Steven A. Kates , Steven Parkinson
Abstract: A method of treating an infection of a lung in a patient in need thereof according to an embodiment includes administering to the patient an effective amount of a compound having the formula:
or a pharmaceutically acceptable salt thereof.
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