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发明申请
US20080292655A1 ENHANCEMENT OF THE IMMUNE RESPONSE FOR VACCINE AND GENE THERAPY APPLICATIONS 有权
疫苗和基因治疗应用免疫应答的增强

ENHANCEMENT OF THE IMMUNE RESPONSE FOR VACCINE AND GENE THERAPY APPLICATIONS
摘要：
Expression cassettes are provided comprising a promoter operably linked to a nucleic acid molecule which, when transcribed in vivo, forms double-stranded RNA that induces the production of interferon. Expression cassettes also are provided comprising a promoter operably linked to a ribozyme or antisense nucleic acid molecule which, when transcribed in vivo, forms a ribozyme or antisense RNA molecule that stimulates an immune response. In addition, expression cassettes are provided comprising a promoter operably linked to a ribozyme or antisense nucleic acid molecule which, when transcribed in vivo, stimulates apoptosis. Finally, gene delivery vectors are provided which contain such expression cassettes, host cells containing the gene delivery vectors, and methods of utilizing the expression cassettes, gene delivery vectors, and host cells.
摘要（中）：

提供了表达盒，其包括可操作地连接到核酸分子的启动子，其在体内转录时形成诱导产生干扰素的双链RNA。 还提供了包含与核酶或反义核酸分子可操作地连接的启动子的表达盒，其在体内转录时形成刺激免疫应答的核酶或反义RNA分子。 此外，提供了包含可操作地连接到核酶或反义核酸分子的启动子的表达盒，其在体内转录时刺激细胞凋亡。 最后，提供含有这种表达盒的基因递送载体，含有基因递送载体的宿主细胞，以及利用表达盒，基因递送载体和宿主细胞的方法。

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