发明申请
US20080293137A1 COMPOUNDS THAT ABROGATE DNA DAMAGE INDUCED CELL CYCLE G2 CHECKPOINT AND/OR AUGMENT ANTI-CANCER ACTIVITY OF DNA-DAMAGING TREATMENTS
失效
DNA损伤诱导的细胞周期G2检测点和/或损伤DNA损伤治疗的抗癌活性的化合物
- 专利标题： COMPOUNDS THAT ABROGATE DNA DAMAGE INDUCED CELL CYCLE G2 CHECKPOINT AND/OR AUGMENT ANTI-CANCER ACTIVITY OF DNA-DAMAGING TREATMENTS
- 专利标题（中）： DNA损伤诱导的细胞周期G2检测点和/或损伤DNA损伤治疗的抗癌活性的化合物
-
申请号： US12131639申请日： 2008-06-02
-
公开(公告)号： US20080293137A1公开(公告)日： 2008-11-27
- 发明人: TAKUMI KAWABE , Hidetaka Kobayashi
- 申请人： TAKUMI KAWABE , Hidetaka Kobayashi
- 申请人地址： JP Numazu-city
- 专利权人： CanBas Co., Ltd.
- 当前专利权人： CanBas Co., Ltd.
- 当前专利权人地址： JP Numazu-city
- 主分类号： C12N5/00
- IPC分类号： C12N5/00 ; A61P35/00
摘要：
The invention provides compositions and methods to inhibit the cell cycle G2 checkpoint, in particular the DNA-damage-induced G2 checkpoint, in mammalian cells including human cells. Specifically, the invention provides compositions and methods to sensitize cells to DNA-damaging agents by abrogating the cell cycle G2 checkpoint. Compounds of the invention are used to treat proliferative disorders such as cancer. The invention provides compositions and methods for selectively sensitizing G1 checkpoint impaired cancer cells to DNA-damaging agents and treatments.
公开/授权文献
信息查询
