发明申请
- 专利标题： Arginine Analogs, and Methods for Their Synthesis and Use
- 专利标题（中）： 精氨酸类似物及其合成和使用方法
-
申请号： US11795173申请日： 2006-01-19
-
公开(公告)号： US20080293920A1公开(公告)日： 2008-11-27
- 发明人: Kenneth F. Buechler , Mariusz G. Banaszczyk , Joseph Barry Noar , Violeta Dinauer
- 申请人： Kenneth F. Buechler , Mariusz G. Banaszczyk , Joseph Barry Noar , Violeta Dinauer
- 国际申请： PCT/US06/01892 WO 20060119
- 主分类号： C07C229/04
- IPC分类号： C07C229/04 ; C07K14/765 ; C07K14/00 ; C07H21/00 ; C07D207/40
摘要：
The present invention relates to novel arginine analogs, and methods for their synthesis and use. Such analogs are designed to provide a protected or free thiol (—SH) group, thereby providing a convenient linkage chemistry for coupling to a suitable group on a target such as a protein, polypeptide, detectable label or solid phase, and at a site distal to the guanidino group. Arginine analog conjugates are useful for generating antibodies that can bind specifically with dimethylarginine, which can be detected using such antibodies in immunoassays.
公开/授权文献
- US07879979B2 Arginine analogs, and methods for their synthesis and use 公开/授权日：2011-02-01
信息查询
