An information processing system includes a first processor that accesses a first memory, a second processor that accesses a second memory, and a data transfer unit for executing data transfer between the first memory and the second memory. The first processor executes functions of translating an instruction out of instructions included in the program except a memory access instruction into an instruction for the second processor and translating the memory access instruction into an instruction sequence containing a call instruction of the program to transfer the access data on the first memory to the second memory via a data transfer unit.