A short distance wireless data transmission system and method which are capable of minimizing data loss are disclosed. The short distance wireless data transmission system can monitor variation amount of memory data, which is buffered in the master side when data transmission errors occur, can perform re-transmission of data having transmission errors, and can perform a change toward new replacement channel without interference if variation amount of memory data, which is buffered therein, exceeds a predetermined reference value to re-transmit from data in which the first transmission error occurs thereto, such that real time data cannot be lost, although a channel change is generated by successive channel interference.