发明申请
US20080312332A1 G Protein-Coupled Receptor Antagonist and Its Use for Preventing and Treating Alzheimer's Disease
有权
G蛋白偶联受体拮抗剂及其用于预防和治疗阿尔茨海默病的用途
- 专利标题: G Protein-Coupled Receptor Antagonist and Its Use for Preventing and Treating Alzheimer's Disease
- 专利标题(中): G蛋白偶联受体拮抗剂及其用于预防和治疗阿尔茨海默病的用途
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申请号: US12159183申请日: 2006-12-26
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公开(公告)号: US20080312332A1公开(公告)日: 2008-12-18
- 发明人: Gang Pei , Yanxiang Ni , Xiaohui Zhao
- 申请人: Gang Pei , Yanxiang Ni , Xiaohui Zhao
- 申请人地址: CN Shanghai
- 专利权人: Shanghai Institues for Biological Sciences, Chinese Academy of Sciences
- 当前专利权人: Shanghai Institues for Biological Sciences, Chinese Academy of Sciences
- 当前专利权人地址: CN Shanghai
- 优先权: CN200510112005.4 20051226; CN200610162480.7 20061117
- 国际申请: PCT/CN2006/003595 WO 20061226
- 主分类号: A61K31/138
- IPC分类号: A61K31/138 ; G01N33/566 ; A61P25/28
摘要:
A method for screening a reagent for treating or preventing Alzheimer's disease or related neurological pathology includes the steps of: (a) activating a receptor and determining a first extent of endocytosis of the receptor, wherein the receptor is a G-protein coupled receptor that associates with presenilin-1; (b) activating the receptor under the same conditions as in step (a), in the presence of a candidate reagent, and determining a second extent of endocytosis of the receptor; (c) determining a difference between the first extent of endocytosis and the second extent of endocytosis; and (d) repeating steps (a)-(c), if the difference is less than a threshold. Uses of receptor antagonists for manufacturing medicaments for treating or preventing Alzheimer's disease or related neurological pathology, wherein the receptor antagonists inhibit endocytosis of a G-protein coupled receptor that associates with presenilin-1 during endocytosis.