公开(公告)号：US20120004254A1

公开(公告)日：2012-01-05

申请号：US13214907

申请日：2011-08-22

申请人： Gang Pei ,  Yanxiang Ni ,  Xiaohui Zhao

发明人： Gang Pei ,  Yanxiang Ni ,  Xiaohui Zhao

IPC分类号： A61K31/485 ,  A61K31/137 ,  A61P25/00 ,  C12Q1/37 ,  G01N33/566 ,  A61P25/28 ,  A61K31/138 ,  C12Q1/02

CPC分类号： G01N33/5035 ,  G01N2333/726 ,  G01N2500/10 ,  G01N2800/2821

摘要： The invention discloses methods for screening a reagent for treating or preventing Alzheimer's disease or related neurological pathology. A method according to the invention includes the steps of: (a) activating a receptor and determining a first extent of endocytosis of the receptor, wherein the receptor is a G-protein coupled receptor that associates with presenilin-1; (b) activating the receptor under the same conditions as in step (a), in the presence of a candidate reagent, and determining a second extent of endocytosis of the receptor; (c) determining a difference between the first extent of endocytosis and the second extent of endocytosis; and (d) repeating steps (a)-(c), if the difference is less than a threshold. The invention also disclose uses of receptor antagonists for manufacturing medicaments for treating or preventing Alzheimer's disease or related neurological pathology, wherein the receptor antagonists inhibit endocytosis of a G-protein coupled receptor that associates with presenilin-1 during endocytosis.

摘要翻译： 本发明公开了用于筛选用于治疗或预防阿尔茨海默病或相关神经病理学的试剂的方法。 根据本发明的方法包括以下步骤：（a）激活受体并确定受体的第一内吞程度，其中该受体是与早老素-1相关的G蛋白偶联受体; （b）在与候选试剂的存在下在与步骤（a）相同的条件下活化受体，并确定受体的第二程度的胞吞作用; （c）确定第一内吞程度与第二内吞程度之间的差异; 和（d）如果差值小于阈值，则重复步骤（a） - （c）。 本发明还公开了受体拮抗剂用于制备用于治疗或预防阿尔茨海默病或相关神经病理学的药物的用途，其中所述受体拮抗剂抑制内吞作用期间与早老蛋白-1相关的G蛋白偶联受体的内吞作用。

公开(公告)号：US08026073B2

公开(公告)日：2011-09-27

申请号：US12159183

申请日：2006-12-26

申请人： Gang Pei ,  Yanxiang Ni ,  Xiaohui Zhao

发明人： Gang Pei ,  Yanxiang Ni ,  Xiaohui Zhao

IPC分类号： G01N33/53

CPC分类号： G01N33/5035 ,  G01N2333/726 ,  G01N2500/10 ,  G01N2800/2821

摘要： A method for screening a reagent for treating or preventing Alzheimer's disease or related neurological pathology includes the steps of: (a) activating a receptor and determining a first extent of endocytosis of the receptor, wherein the receptor is a G-protein coupled receptor that associates with presenilin-1; (b) activating the receptor under the same conditions as in step (a), in the presence of a candidate reagent, and determining a second extent of endocytosis of the receptor; (c) determining a difference between the first extent of endocytosis and the second extent of endocytosis; and (d) repeating steps (a)-(c), if the difference is less than a threshold. Uses of receptor antagonists for manufacturing medicaments for treating or preventing Alzheimer's disease or related neurological pathology, wherein the receptor antagonists inhibit endocytosis of a G-protein coupled receptor that associates with presenilin-1 during endocytosis.

摘要翻译： 用于筛选用于治疗或预防阿尔茨海默病或相关神经病理学的试剂的方法包括以下步骤：（a）激活受体并测定受体的第一内吞程度，其中所述受体是G蛋白偶联受体， 与早老素-1; （b）在与候选试剂的存在下在与步骤（a）相同的条件下活化受体，并确定受体的第二程度的胞吞作用; （c）确定第一内吞程度与第二内吞程度之间的差异; 和（d）如果差值小于阈值，则重复步骤（a） - （c）。 用于制备用于治疗或预防阿尔茨海默病或相关神经病理学的药物的受体拮抗剂的用途，其中所述受体拮抗剂抑制内吞作用期间与早老蛋白-1相关的G蛋白偶联受体的内吞。

公开(公告)号：US20080312332A1

公开(公告)日：2008-12-18

申请号：US12159183

申请日：2006-12-26

申请人： Gang Pei ,  Yanxiang Ni ,  Xiaohui Zhao

发明人： Gang Pei ,  Yanxiang Ni ,  Xiaohui Zhao

IPC分类号： A61K31/138 ,  G01N33/566 ,  A61P25/28

CPC分类号： G01N33/5035 ,  G01N2333/726 ,  G01N2500/10 ,  G01N2800/2821

摘要： A method for screening a reagent for treating or preventing Alzheimer's disease or related neurological pathology includes the steps of: (a) activating a receptor and determining a first extent of endocytosis of the receptor, wherein the receptor is a G-protein coupled receptor that associates with presenilin-1; (b) activating the receptor under the same conditions as in step (a), in the presence of a candidate reagent, and determining a second extent of endocytosis of the receptor; (c) determining a difference between the first extent of endocytosis and the second extent of endocytosis; and (d) repeating steps (a)-(c), if the difference is less than a threshold. Uses of receptor antagonists for manufacturing medicaments for treating or preventing Alzheimer's disease or related neurological pathology, wherein the receptor antagonists inhibit endocytosis of a G-protein coupled receptor that associates with presenilin-1 during endocytosis.

摘要翻译： 用于筛选用于治疗或预防阿尔茨海默病或相关神经病理学的试剂的方法包括以下步骤：（a）激活受体并测定受体的第一内吞程度，其中所述受体是G蛋白偶联受体， 与早老素-1; （b）在与候选试剂的存在下在与步骤（a）相同的条件下活化受体，并确定受体的第二程度的胞吞作用; （c）确定第一内吞程度与第二内吞程度之间的差异; 和（d）如果差值小于阈值，则重复步骤（a） - （c）。 用于制备用于治疗或预防阿尔茨海默病或相关神经病理学的药物的受体拮抗剂的用途，其中所述受体拮抗剂抑制内吞作用期间与早老蛋白-1相关的G蛋白偶联受体的内吞。

公开(公告)号：USD660270S1

公开(公告)日：2012-05-22

申请号：US29382161

申请日：2010-12-29

申请人： Ze Yuan ,  Xiaohui Zhao ,  Dayong Cui

设计人： Ze Yuan ,  Xiaohui Zhao ,  Dayong Cui

公开(公告)号：US08180394B2

公开(公告)日：2012-05-15

申请号：US12437876

申请日：2009-05-08

申请人： Bin Zhang ,  Xiaohui Zhao

发明人： Bin Zhang ,  Xiaohui Zhao

IPC分类号： H04M1/00

CPC分类号： H04M1/0247 ,  H04M1/0225 ,  H04M1/0231 ,  H04M2250/18

摘要： A wireless terminal in a wireless communication field is provided, which not only includes a top layer body and a bottom layer body, but also includes at least one extending layer body to provide an extending function. The extending layer body is connected in a stacked way to the top layer body or the bottom layer body. The extending function of the wireless terminal is realized through the extending layer body, so that the wireless terminal has powerful capabilities of extending and combining the functions.

摘要翻译： 提供了一种无线通信领域中的无线终端，其不仅包括顶层体和底层体，而且还包括至少一个延伸层体以提供延伸功能。 延伸层体以堆叠的方式连接到顶层体或底层体。 通过扩展层主体实现无线终端的扩展功能，无线终端具有强大的功能扩展和组合功能。

公开(公告)号：US20090221336A1

公开(公告)日：2009-09-03

申请号：US12437876

申请日：2009-05-08

申请人： Bin Zhang ,  Xiaohui Zhao

发明人： Bin Zhang ,  Xiaohui Zhao

IPC分类号： H04M1/00

CPC分类号： H04M1/0247 ,  H04M1/0225 ,  H04M1/0231 ,  H04M2250/18

摘要： A wireless terminal in a wireless communication field is provided, which not only includes a top layer body and a bottom layer body, but also includes at least one extending layer body to provide an extending function. The extending layer body is connected in a stacked way to the top layer body or the bottom layer body. The extending function of the wireless terminal is realized through the extending layer body, so that the wireless terminal has powerful capabilities of extending and combining the functions.

摘要翻译： 提供了一种无线通信领域中的无线终端，其不仅包括顶层体和底层体，而且还包括至少一个延伸层体以提供延伸功能。 延伸层体以堆叠的方式连接到顶层体或底层体。 通过扩展层主体实现无线终端的扩展功能，无线终端具有强大的功能扩展和组合功能。