发明申请
- 专利标题： Polynucelotides encoding novel variants of the TRP channel family member, LTRPC3
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申请号： US12220155申请日： 2008-07-22
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公开(公告)号： US20080318257A1公开(公告)日： 2008-12-25
- 发明人: Ning Lee , Jian Chen , John N. Feder , Shujian Wu , Michael A. Blanar , David K. Bol , Paul C. Levesque , Lucy Sun
- 申请人： Ning Lee , Jian Chen , John N. Feder , Shujian Wu , Michael A. Blanar , David K. Bol , Paul C. Levesque , Lucy Sun
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 主分类号： G01N33/53
- IPC分类号： G01N33/53 ; C07K16/18 ; C12N5/06 ; G01N33/566
摘要：
The present invention provides novel polynucleotides encoding LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
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