Polynucleotide encoding a novel TRP channel family member, LTRPC3, and splice variants thereof
    2.
    发明申请
    Polynucleotide encoding a novel TRP channel family member, LTRPC3, and splice variants thereof 有权
    编码新型TRP通道家族成员的多核苷酸,LTRPC3及其剪接变体

    公开(公告)号:US20080274505A1

    公开(公告)日:2008-11-06

    申请号:US12152547

    申请日:2008-05-15

    摘要: The present invention provides novel polynucleotides encoding LTRPC3 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of LTRPC3 polypeptides, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译: 本发明提供了编码LTRPC3多肽的新型多核苷酸,其片段及其同源物。 本发明还提供了分别编码LTRPC3多肽,LTRPC3b,LTRPC3c,LTRPC3d,LTRPC3e和LTRPC3f的变体和剪接变体的多核苷酸。 还提供了载体,宿主细胞,抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型LTRPC3,LTRPC3b,LTRPC3c,LTRPC3d,LTRPC3e和LTRPC3f多肽应用于诊断,治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotide encoding a novel TRP channel family member, LTRPC3, and splice variants thereof
    3.
    发明授权
    Polynucleotide encoding a novel TRP channel family member, LTRPC3, and splice variants thereof 有权
    编码新型TRP通道家族成员的多核苷酸,LTRPC3及其剪接变体

    公开(公告)号:US07767418B2

    公开(公告)日:2010-08-03

    申请号:US12152547

    申请日:2008-05-15

    摘要: The present invention provides novel polynucleotides encoding LTRPC3 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of LTRPC3 polypeptides, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f, respectively. Also provided are vectors, host cells, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译: 本发明提供了编码LTRPC3多肽的新型多核苷酸,其片段及其同源物。 本发明还提供了分别编码LTRPC3多肽,LTRPC3b,LTRPC3c,LTRPC3d,LTRPC3e和LTRPC3f的变体和剪接变体的多核苷酸。 还提供载体,宿主细胞,以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型LTRPC3,LTRPC3b,LTRPC3c,LTRPC3d,LTRPC3e和LTRPC3f多肽应用于诊断,治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    TRP channel family member, LTRPC3 polypeptides
    4.
    发明授权
    TRP channel family member, LTRPC3 polypeptides 有权
    TRP频道家庭成员,LTRPC3e

    公开(公告)号:US07504481B2

    公开(公告)日:2009-03-17

    申请号:US10405793

    申请日:2003-03-28

    摘要: The present invention provides novel polynucleotides encoding LTRPC3 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of LTRPC3 polypeptides, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing the novel LTRPC3, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译: 本发明提供了编码LTRPC3多肽的新型多核苷酸,其片段及其同源物。 本发明还提供了分别编码LTRPC3多肽,LTRPC3b,LTRPC3c,LTRPC3d,LTRPC3e和LTRPC3f的变体和剪接变体的多核苷酸。 还提供了用于产生新型LTRPC3,LTRPC3b,LTRPC3c,LTRPC3d,LTRPC3e和LTRPC3f多肽的载体,宿主细胞,抗体以及重组和合成方法。 本发明还涉及将这些新型LTRPC3,LTRPC3b,LTRPC3c,LTRPC3d,LTRPC3e和LTRPC3f多肽应用于诊断,治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotide encoding a TRP channel family member, TRP-PLIK2
    5.
    发明授权
    Polynucleotide encoding a TRP channel family member, TRP-PLIK2 有权
    编码TRP通道家族成员的多核苷酸TRP-PLIK2

    公开(公告)号:US07223557B2

    公开(公告)日:2007-05-29

    申请号:US10153244

    申请日:2002-05-22

    CPC分类号: C07K14/705

    摘要: The present invention provides novel polynucleotides encoding TRP-PLIK2 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of TRP-PLIK2 polypeptides, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel TRP-PLIK2, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译: 本发明提供了编码TRP-PLIK2多肽的新型多核苷酸,其片段和同源物。 本发明还提供分别编码TRP-PLIK2多肽,TRP-PLIK2b,TRP-PLIK2c和TRP-PLIK2d的变体和剪接变体的多核苷酸。 还提供了载体,宿主细胞,抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型TRP-PLIK2,TRP-PLIK2b,TRP-PLIK2c和TRP-PLIK2d多肽应用于诊断,治疗和/或预防与这些相关的各种疾病和/或病症的诊断和治疗方法 多肽。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Metalloprotease highly expressed in the testis, MMP-29
    6.
    发明授权
    Metalloprotease highly expressed in the testis, MMP-29 有权
    金属蛋白酶在睾丸中高度表达,MMP-29

    公开(公告)号:US07285633B2

    公开(公告)日:2007-10-23

    申请号:US11313356

    申请日:2005-12-21

    IPC分类号: A61K38/17

    CPC分类号: C12N9/6489

    摘要: The present invention provides novel polynucleotides encoding MMP-29 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel MMP-29 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译: 本发明提供了编码MMP-29多肽的新型多核苷酸,其片段和同源物。 还提供了载体,宿主细胞,抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型MMP-29多肽应用于诊断,治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotides encoding a human cell surface protein with immunoglobulin folds, BGS-19
    7.
    发明授权
    Polynucleotides encoding a human cell surface protein with immunoglobulin folds, BGS-19 有权
    编码具有免疫球蛋白折叠的人细胞表面蛋白的多核苷酸,BGS-19

    公开(公告)号:US07202056B2

    公开(公告)日:2007-04-10

    申请号:US10403938

    申请日:2003-03-28

    摘要: The present invention provides novel polynucleotides encoding BGS-19 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying the novel BGS-19 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译: 本发明提供了编码BGS-19多肽的新型多核苷酸,其片段和同源物。 还提供了载体,宿主细胞,抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将新型BGS-19多肽应用于诊断,治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Splice variants of human G-protein coupled receptor HGPRBMY29 (HGPRMBY29SV2)
    8.
    发明授权
    Splice variants of human G-protein coupled receptor HGPRBMY29 (HGPRMBY29SV2) 有权
    人G蛋白偶联受体HGPRBMY29(HGPRBMY29SV2)的剪接变体

    公开(公告)号:US08124729B2

    公开(公告)日:2012-02-28

    申请号:US11891240

    申请日:2007-08-09

    摘要: The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译: 本发明提供编码HGPRBMY28和HGPRBMY29多肽的新型多核苷酸,其片段及其同源物。 本发明还提供编码HGPRBMY29多肽,HGPRBMY29v1和HGPRBMY29v2的剪接变体的多核苷酸。 还提供了载体,宿主细胞,抗体以及用于产生所述多肽的重组和合成方法。 还提供了载体,宿主细胞,抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY28,HGPRBMY29,HGPRBMY29v1和HGPRBMY29v2多肽应用于诊断,治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Antibodies directed to G-protein coupled receptor HGPRBMY29sv1
    9.
    发明授权
    Antibodies directed to G-protein coupled receptor HGPRBMY29sv1 有权
    针对G蛋白偶联受体HGPRBMY29sv1的抗体

    公开(公告)号:US07635758B2

    公开(公告)日:2009-12-22

    申请号:US11890963

    申请日:2007-08-08

    IPC分类号: C07K16/00 C12P21/08

    摘要: The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing these polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing these polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译: 本发明提供编码HGPRBMY28和HGPRBMY29多肽的新型多核苷酸,其片段及其同源物。 本发明还提供编码HGPRBMY29多肽,HGPRBMY29v1和HGPRBMY29v2的剪接变体的多核苷酸。 还提供了载体,宿主细胞,抗体以及用于产生这些多肽的重组和合成方法。 还提供了载体,宿主细胞,抗体以及用于产生这些多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY28,HGPRBMY29,HGPRBMY29v1和HGPRBMY29v2多肽应用于诊断,治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotides encoding three novel human cell surface proteins with leucine rich repeats and immunologobulin folds, BGS2, 3, and 4 and variants thereof
    10.
    发明授权
    Polynucleotides encoding three novel human cell surface proteins with leucine rich repeats and immunologobulin folds, BGS2, 3, and 4 and variants thereof 失效
    编码具有富含亮氨酸重复序列和免疫球蛋白折叠的三种新型人细胞表面蛋白的多核苷酸,BGS2,3和4及其变体

    公开(公告)号:US07223558B2

    公开(公告)日:2007-05-29

    申请号:US10193477

    申请日:2002-07-11

    CPC分类号: C07K14/705 A61K38/00

    摘要: The present invention provides novel polynucleotides encoding BGS-2, 3, and 4 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-2, 3, and 4 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译: 本发明提供了编码BGS-2,3和4多肽的新型多核苷酸,其片段及其同源物。 还提供了载体,宿主细胞,抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型BGS-2,3和4多肽应用于诊断,治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。