发明申请
US20090004177A1 Combination Treatment with t-PA Variant and Low Molecular Weight Heparin
审中-公开
t-PA变体和低分子量肝素联合治疗
- 专利标题： Combination Treatment with t-PA Variant and Low Molecular Weight Heparin
- 专利标题（中）： t-PA变体和低分子量肝素联合治疗
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申请号： US12185588申请日： 2008-08-04
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公开(公告)号： US20090004177A1公开(公告)日： 2009-01-01
- 发明人: Paul Armstrong , Hal Barron , Silvano Berioli , Frederique Bigonzi , Erich Bluhmki , Richard Chin , Christopher Granger , Frans Van De Werf , Fong Wang-Clow
- 申请人： Paul Armstrong , Hal Barron , Silvano Berioli , Frederique Bigonzi , Erich Bluhmki , Richard Chin , Christopher Granger , Frans Van De Werf , Fong Wang-Clow
- 主分类号： A61K38/49
- IPC分类号： A61K38/49 ; A61P9/10 ; G06Q50/00
摘要：
The invention concerns an improved therapeutic regimen for the treatment of thrombolytic disorders, such as acute myocardial infarction (AMI). In particular, the present invention concerns the treatment of thrombolytic disorders, e.g., AMI, with a combination of a tissue plasminogen activator (t-PA) variant having improved fibrin specificity and extended plasma half-life when compared with wild-type human t-PA and a low molecular weight heparin.
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