发明申请
US20090004225A1 TOXIN COMPOUNDS WITH ENHANCED MEMBRANE TRANSLOCATION CHARACTERISTICS
审中-公开
具有增强膜转录特性的毒素化合物
- 专利标题： TOXIN COMPOUNDS WITH ENHANCED MEMBRANE TRANSLOCATION CHARACTERISTICS
- 专利标题（中）： 具有增强膜转录特性的毒素化合物
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申请号： US12192613申请日： 2008-08-15
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公开(公告)号： US20090004225A1公开(公告)日： 2009-01-01
- 发明人: Ester Fernandez-Salas , Lance E. Steward , Wei-Jen Lin , Kei Roger Aoki , George Sachs
- 申请人： Ester Fernandez-Salas , Lance E. Steward , Wei-Jen Lin , Kei Roger Aoki , George Sachs
- 专利权人： Allergan, Inc.
- 当前专利权人： Allergan, Inc.
- 主分类号： A61K39/08
- IPC分类号： A61K39/08 ; C07K14/33
摘要：
The present invention relates to a compound comprising a toxin linked to a translocator. Non-limiting examples of toxins of the present invention are botulinum toxin, butyricum toxin, tetani toxins and the light chains thereof. In some embodiments, the translocator of the present invention comprises a protein transduction domain.
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