发明申请
- 专利标题： Process for Producing Glycolic Acid from Formaldehyde And Hydrogen Cyanide
- 专利标题（中）： 从甲醛和氰化氢生产乙醇酸的方法
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申请号： US12189869申请日： 2008-08-12
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公开(公告)号： US20090004707A1公开(公告)日： 2009-01-01
- 发明人: Robert DiCosimo , Anna Panova , Jeffery Scott Thompson , Robert D. Fallon , Thomas Foo , F. Glenn Gallagher , Xu Li , George C. Fox , Joseph J. Zaher , Mark S. Payne , Daniel P. O'Keefe
- 申请人： Robert DiCosimo , Anna Panova , Jeffery Scott Thompson , Robert D. Fallon , Thomas Foo , F. Glenn Gallagher , Xu Li , George C. Fox , Joseph J. Zaher , Mark S. Payne , Daniel P. O'Keefe
- 申请人地址： US DE Wilmington
- 专利权人： E.I. Du Pont De Nemours And Company
- 当前专利权人： E.I. Du Pont De Nemours And Company
- 当前专利权人地址： US DE Wilmington
- 主分类号： C12P7/42
- IPC分类号： C12P7/42
摘要：
A process is provided for producing glycolic acid from formaldehyde and hydrogen cyanide. More specifically, heat-treated formaldehyde and hydrogen cyanide are reacted to produce glycolonitrile having low concentrations of impurities. The glycolonitrile is subsequently converted to an aqueous solution of ammonium glycolate using an enzyme catalyst having nitrilase activity derived from Acidovorax facilis 72W (ATCC 57746). Glycolic acid is recovered in the form of the acid or salt from the aqueous ammonium glycolate solution using a variety of methods described herein.