Invention Application
- Patent Title: Nitro-Imidazole Hypoxia Imaging Agents
- Patent Title (中): 硝基咪唑缺氧成像剂
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Application No.: US12098390Application Date: 2008-04-04
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Publication No.: US20090010846A1Publication Date: 2009-01-08
- Inventor: Hartmuth C. Kolb , Joseph C. Walsh , Umesh B. Gangadharmath , Farhad Karimi , Henry Clifton Padgett , Dhanalakshmi Kasi , Zhiyong Gao , Qianwa Liang , Thomas Lee Collier , Brian A. Duclos , Tieming Zhao
- Applicant: Hartmuth C. Kolb , Joseph C. Walsh , Umesh B. Gangadharmath , Farhad Karimi , Henry Clifton Padgett , Dhanalakshmi Kasi , Zhiyong Gao , Qianwa Liang , Thomas Lee Collier , Brian A. Duclos , Tieming Zhao
- Assignee: SIEMENS MEDICAL SOLUTIONS USA, INC.
- Current Assignee: SIEMENS MEDICAL SOLUTIONS USA, INC.
- Main IPC: A61K51/04
- IPC: A61K51/04 ; C07D403/12 ; A61P35/00
Abstract:
The present invention relates to novel radioactively labeled bioreducible tracers of Formula I useful for detecting hypoxic tumors or ischemic tissue in vivo. In one embodiment, the tracers consist of a 2-nitroimidazole moiety, a triazole, metabolically stable linker with pharmacokinetics enhancing substituents, and a radioisotope. The preferred in vivo imaging modality is positron emission tomography.
Public/Granted literature
- US07807394B2 Nitro-imidazole hypoxia imaging agents Public/Granted day:2010-10-05
Information query
